The American Journal of Surgery
Volume 182, Issue 1 , Pages 89-92, July 2001

Influence of gender on intraluminal thrombus of abdominal aortic aneurysms

  • Hiroshi Yasuhara, M.D.

      Affiliations

    • Department of Surgery, Teikyo University Ichihara Hospital, 3426-3 Anesaki, Ichihara City, Chiba 299-0111 Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81(3)3268-0083; fax: +81(3)3268-0083
    • ,
  • Nobusuke Ohara, M.D.

      Affiliations

    • Department of Surgery, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Hirokazu Nagawa, M.D.

      Affiliations

    • Department of Surgery, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Received 14 August 2000; received in revised form 20 January 2001

Abstract 

Background: The mechanisms of formation of intraluminal thrombus (ILT) of abdominal aortic aneurysms (AAA) remain unknown. The aim of this study was to investigate the pathogenesis of AAA by analysis of ILT.

Methods: We retrospectively analyzed the size of ILT in 98 consecutive patients with AAA undergoing abdominal computed tomography (CT) examination. The volume of ILT was estimated by the area ratio of ILT in CT images. Important baseline variables related to small ILT were determined using logistic-regression analysis.

Results: There were two apparent peaks in the distribution of ILT ratio. Thirteen of 98 patients had negligible ILT with ratio ≤0.1. Female gender was the only patient characteristic independently significantly correlated with small ILT (odds ratio 5.214, P = 0.0096).

Conclusion: Our findings provide important evidence that AAA is formed by at least two different pathogenic processes. It is likely that this difference in mechanisms may be caused partly by sex hormones.

Keywords:  Abdominal aortic aneurysm, Intraluminal thrombus, Pathogenesis

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PII: S0002-9610(01)00653-5

The American Journal of Surgery
Volume 182, Issue 1 , Pages 89-92, July 2001

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