The American Journal of Surgery
Volume 183, Issue 6 , Pages 650-654, June 2002

Conservative surgery and radiation therapy for macroscopically multiple ipsilateral invasive breast cancers

  • L.Chinsoo Cho, M.D.

      Affiliations

    • Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, University of Texas Moncrief Cancer Center, Fort Worth, TX, USA
    • ,
  • Neil Senzer, M.D.

      Affiliations

    • Department of Radiation Oncology, Baylor University Medical Center, Dallas, TX, USA
    • ,
  • George N Peters, M.D.

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1-214-648-7750; fax: +1-214-648-1917
    • The University of Texas Southwestern Center for Breast Care, 5323 Harry Hines Blvd., Dallas, TX 75390-9161, USA

Received 15 August 2001; received in revised form 5 January 2002

Abstract 

Background: The presence of macroscopically multiple ipsilateral invasive breast cancer (MMIIBC) has been considered a contraindication for breast conservation. Early series reported high rates of local recurrence. A treatment regimen was developed to accommodate patient requests for breast conservation in MMIIBC.

Methods: We reviewed medical records of the 15 MMIIBC patients who underwent partial mastectomy followed by radiation between 1989 and 1997. All patients had 2 or more separate macroscopic tumors greater than 2 mm in diameter. After tumor excision, all specimens were evaluated; the protocol required surgical margins of at least 2 mm.

Results: As of June 2000 (median follow-up 76 months), 14 patients (93%) were alive without evidence of disease. One patient died of systemic disease without local recurrence.

Conclusions: In selected cases, the combination of breast conservative surgery and radiation therapy with systemic therapy results in acceptable local-regional control. Patients who present with MMIIBC with clear surgical margins should be considered for breast conservation.

Keywords:  Breast conservation, Multiple ipsilateral invasive breast cancers, Clear surgical margins

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PII: S0002-9610(02)00864-4

The American Journal of Surgery
Volume 183, Issue 6 , Pages 650-654, June 2002

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