The American Journal of Surgery
Volume 187, Issue 1 , Pages 20-23 , January 2004

Omeprazole is more effective than a histamine H2-receptor blocker for maintaining a persistent elevation of gastric pH after colon resection for cancer

  • Tzu-Chi Hsu, M.D.

      Affiliations

    • Colon and Rectal Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan
    • Department of Surgery, Taipei Medical College, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +011-8862-2543-3535; fax: +011-8862-2543-3642.
    • ,
  • Chiu-Feng Su, R.Ph.

      Affiliations

    • Department of Pharmacy, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Shu-Ching Leu, R.N.

      Affiliations

    • Colon and Rectal Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Pi-Chen Huang, R.N.

      Affiliations

    • Colon and Rectal Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Tsang-En Wang, M.D.

      Affiliations

    • Gastrointestinal Medicine, Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Cheng-Hsin Chu, M.D.

      Affiliations

    • Gastrointestinal Medicine, Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan

Received 22 April 2002 ,Revised 28 October 2002

References 

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  2. Lucas CE, Sugawa C, Riddle, et al. Normal history and surgical dilemma of stress gastric bleeding. Arch Surg 1971;102:266–73
  3. Levine RJ, Senay EC. Studies on the role of acid in the pathogenesis of experimental stress ulcers. Psychosom Med. 1972;32:61
  4. Skilman JJ. Pathogenesis of peptic ulcer (a selective review). Surgery. 1974;76:515–523
  5. Wilcox CM, Spenney JG. Stress ulcer prophylaxis in medical patients (who, what, and how much?). Am J Surg. 1988;83:199–221
  6. Kohler B, Benz C, Maier M, et al.  Gastric pH-monitoring in patients with acute ulcer bleeding under continuous intravenous therapy with omeprazole or ranitidine. Gastroenterology. 1994;106:A109
  7. Kiilerich S, Rannem T, Elsborg L. Effect of intravenous omeprazole and ranitidine on twenty-four-hour intragastric pH in patients with a history of duodenal ulcer. Digestion. 1995;56:25–30
  8. Raff T, Germann G, Hartmann B. The value of early enteral nutrition in the severely burned patient. Burns. 1997;23:313–318
  9. Merki HS, Wilder-Smith CH. Do continuous infusions of omeprazole and ranitidine retain their effect with prolonged dosing?. Gastroenterology. 1994;106:60–64
  10. Labex J, Peitz U, Leusing C, et al.  Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding (a prospective randomized controlled study). Gut. 1997;4:36–41
  11. Netzer P, Gaia C, Sandoz M, et al.  Effect of repeated injection and continuous infusion of omeprazole and ranitidine on intragastric pH over 72 hours. Am J Gastroenterol. 1999;94:351–357
  12. Lau JYW, Sung JJY, Lee KKC, et al.  Effect of intravenous omeprazole on recurrent bleeding peptic ulcers. N Engl J Med. 2000;343:310–316

PII: S0002-9610(03)00431-8

doi: 10.1016/j.amjsurg.2002.10.002

The American Journal of Surgery
Volume 187, Issue 1 , Pages 20-23 , January 2004

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