The American Journal of Surgery
Volume 193, Issue 2 , Pages 200-205 , February 2007

Altered esophageal sensory–motor function in patients with persistent symptoms after Nissen fundoplication

  • Jose M. Remes-Troche, M.D.

      Affiliations

    • Section of Neurogastroenterology, Division of Gastroenterology–Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Dr, 4612 JCP, Iowa City, IA 52242, USA
  • ,
  • James Maher, M.D.

      Affiliations

    • Department of Surgery, Virginia Commonwealth University, Richmond, VA
  • ,
  • Ranjit Mudipalli, M.D.

      Affiliations

    • Section of Neurogastroenterology, Division of Gastroenterology–Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Dr, 4612 JCP, Iowa City, IA 52242, USA
  • ,
  • Satish S.C. Rao, M.D., Ph.D., F.R.C.P. (LON)

      Affiliations

    • Section of Neurogastroenterology, Division of Gastroenterology–Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Dr, 4612 JCP, Iowa City, IA 52242, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-319-353-6602; fax: +1-319-353-6399.

Received 25 August 2006 ,Revised 30 October 2006

References 

  1. Frank L, Kleinman L, Ganoczy D, et al. Upper gastrointestinal symptoms in North America: prevalence and relationship to healthcare utilization and quality of life. Dig Dis Sci. 2004;117:30–33
  2. Heading RC. Prevalence of upper gastrointestinal symptoms in the general population: a systematic review. Scand J Gastroenterol. 1999;34(Suppl 231):3–8
  3. Orlando RC. Pathophysiology of gastro esophageal reflux disease: offensive factors and Tissue resistance. In:  Orlando RC editors. Gastroesophageal Reflux Disease. New York, NY: Marcel Dekker; 2000;p. 165–192
  4. Fass R. Distinct phenotypic presentations of gastroesophageal reflux disease: a new view of the natural history. Dig Dis. 2004;22:100–107
  5. Mainie I, Tutuian R, Shay S, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy (A multicentre study using combined ambulatory impedance-pH monitoring). Gut. 2006;55:1398–1402
  6. Tack J, Koek G, Demedts I, et al. Gastroesophageal reflux disease poorly responsive to single-dose proton pump inhibitors in patients without Barrett’s esophagus: acid reflux, bile reflux or both?. Am J Gastroenterol. 2004;99:981–988
  7. Holloway RH, Dent J. Pathophysiology of gastroesophageal reflux: lower esophageal sphincter dysfunction in gastroesophageal reflux disease. Gastroenterol Clin N Am. 1990;19:517–535
  8. Mittal RK, Holloway RH, Penagini R, et al. Transient lower esophageal sphincter relaxation. Gastroenterology. 1995;109:601–610
  9. Kahrilas PJ, Dodds WJ, Hogan WJ. Effect of peristaltic dysfunction on esophageal volume clearance. Gastroenterology. 1988;94:73–80
  10. Pehlivanov N, Liu J, Mittal RK. Sustained esophageal contraction: a motor correlate of heartburn symptom. Am J Physiol Gastrointest Liver Physiol. 2001;281:G743–G751
  11. Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut. 1995;37:7–12
  12. Chahal P, Rao SC. Functional chest pain: nociception and visceral hyperalgesia. J Clin Gastroenterol. 2005;39(suppl 5):S204–S209
  13. Mehta AJ, de Caestecker JS, Camm AJ, et al. Sensitization to painful distention and abnormal sensory perception in the esophagus. Gastroenterology. 1995;108:311–319
  14. Sarkar S, Hobson AR, Furlong PL, et al. Central neural mechanisms mediating human visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol. 2001;281:G1196–G1202
  15. Hu WH, Martin CJ, Talley NJ. Intraesophageal acid perfusion sensitizes the esophagus to mechanical distension: a Barostat study. Am J Gastroenterol. 2000;95:2189–2194
  16. Drewes AM, Reddy H, Staahl C, et al. Sensory-motor response to mechanical stimulation of the esophagus after sensitization with acid. World J Gastroenterol. 2005;11:4367–4374
  17. Fass R, Naliboff B, Higa L, et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology. 1998;115:1363–1373
  18. Mudipalli R, Rao S, Zhao X, Maher J. Altered esophageal sensory and biomechanical properties in GERD. Am J Gastroenterol. 2001;96(Suppl 1):S24
  19. Bammer T, Hinder RA, Klaus , et al. Five- to eight-year outcome of the first laparoscopic Nissen fundoplications. J Gastrointest Surg. 2001;5:42–48
  20. Lafullarde T, Watson DI, Jamieson GG, et al. Laparoscopic Nissen fundoplication: five-year results and beyond. Arch Surg. 2001;136:180–184
  21. Johansson J, Johnsson F, Joelsson B, et al. Outcome 5 years after 360 degree fundoplication for gastroesophageal reflux disease. Br J Surg. 1993;80:46–49
  22. Spechler SJ. The management of patients who have “failed” antireflux surgery. Am J Gastroenterol. 2004;99:552–561
  23. Rao SSC, Hayek B, Summers RW. Impedance planimetry: an integrated approach for assessing sensory, active and passive biomechanical properties of the esophagus. Am J Gastroenterol. 1995;90:431–438
  24. Rao S, Gregersen H, Hayek B, et al. Unexplained chest pain: the hypersensitive, hyperreactive, and poorly compliant esophagus. Ann Int Med. 1996;124:950–958
  25. Rao S, Hayek B, Summers R. Functional chest pain of esophageal origin: hyperalgesia or motor dysfunction. Am J Gastroenterol. 2001;96:2584–2589
  26. Lose G, Colstrup H, Saksager K, et al. A probe for measurement of related values of cross-sectional area and pressure in a biological tube. Med Biol Eng Comput. 1986;24:488–492
  27. De Meester TR, Bonavina L, Albertucci M. Nissen fundoplication for gastroesophageal reflux disease (Evaluation of primary repair in 100 consecutive patients). Ann Surg. 1986;204:9–20
  28. Grande L, Toledo-Pimentel V, Manterola C, et al. Value of Nissen fundoplication in patients with gastro-oesophageal reflux judged by long-term symptoms control. Br J Surg. 1994;81:548–550
  29. Sayuk GS, Clouse RE. Management of esophageal symptoms following fundoplication. Curr Treat Options Gastroenterol. 2005;8:293–303
  30. Kahrilas PJ, Dodds WJ, Hogan WJ, et al. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology. 1986;91:897–904
  31. Mearin F, Vasconez C, Zarate N, et al. Esophageal tone in patients with total aperistalsis: gastroesophageal reflux disease versus achalasia. Am J Physiol Gastrointest Liver Physiol. 2000;279:G374–G379
  32. Jenkinson AD, Scott SM, Yazaki E, et al. Compliance measurement of lower esophageal sphincter and esophageal body in achalasia and gastroesophageal reflux disease. Dig Dis Sci. 2001;46:1937–1942
  33. Sarkar S, Thompson DG, Woolf CJ, et al. Patients with chest pain and occult gastroesophageal reflux demonstrate visceral pain hypersensitivity which may be partially responsive to acid suppression. Am J Gastroenterol. 2004;99:1998–2006
  34. Kern MK, Birn RM, Jaradeh S, et al. Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention. Gastroenterology. 1998;115:1353–1362
  35. Ireland AC, Holloway RH, Toouli J, et al. Mechanisms underlying the antireflux action of fundoplication. Gut. 1993;34:303–308
  36. Pursnani KG, Sataloff DM, Zayas F, et al. Evaluation of the antireflux mechanism following laparoscopic fundoplication. Br J Surg. 1997;84:1157–1161
  37. Lindeboom MA, Ringers J, Straathof JW, et al. Effect of laparoscopic partial fundoplication on reflux mechanisms. Am J Gastroenterol. 2003;98:29–34
  38. Stein HJ, DeMeester TR, Naspetti R, et al. Three-dimensional imaging of the lower esophageal sphincter in gastroesophageal reflux disease. Ann Surg. 1991;214:374–384
  39. Johnsson F, Joelsson B, Gudmundsson K, et al. Effects of fundoplication on the antireflux mechanism. Br J Surg. 1987;74:1111–1114
  40. Martinez de Haro L, Parrilla Paricio P, Ortiz Escandell MA, et al. A manometric study Antireflux mechanism of Nissen fundoplication. Scand J Gastroenterol. 1992;27:417–420
  41. Ortiz Escandell A, Martinez de Haro LF, Parrilla Paricio P, et al. Surgery improves defective oesophageal peristalsis in patients with gastro-oesophageal reflux. Br J Surg. 1991;78:1095–1097
  42. Campos GM, Peters JF, De Meester TR, et al. Multivariate analysis of factors predicting outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg. 1999;292–300
  43. Jackson PG, Gleiber MA, Askari R, et al. Predictors of outcome in 100 consecutive laparoscopic antireflux procedures. Am J Surg. 2001;181:231–235
  44. Rao S, Mudipalli R, Mujica V, et al. An open-label trial of theophylline for functional chest pain. Dig Dis Sci. 2002;47:2763–2768
  45. Varaia I, Logue E, O’Connor C, et al. Randomized trial of sertraline in patients with unexplained chest pain of non cardiac origin. Am Heart J. 2000;140:367–372
  46. Broekaert D, Fischler B, Sifrim D, et al. Influence of citalopram, a selective serotonin reuptake inhibitor, on esophageal hypersensitivity: a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2006;23:365–370
  47. Rodriguez-Stanley S, Zubaidi S, Proskin HM, et al. Effect of tegaserod on esophageal pain threshold, regurgitation and symptom relief in patients with functional heartburn and mechanical sensitivity. Clin Gastroenterol Hepatol. 2006;4:442–450
  48. Peghini PL, Katz PO, Castell DO. Imipramine decreases oesophageal pain perception in human male volunteers. Gut. 1998;42:807–813
  49. Prakash C, Clouse RE. Long term outcome of tricyclic antidepressant treatment of functional chest pain. Dig Dis Sci. 1999;44:81–90
  50. Clouse RE, Lustman PJ, Eckert TC, et al. –Low-dose trazodone for symptomatic patients with esophageal contraction abnormalities (A double-blind, placebo-controlled trial). Gastroenterology. 1987;92:1027–1036
  51. Botoman VA, Rao S, Dunlap P, et al. Motility and GI function studies billing and coding guidelines: a position paper of the American Motility Society. Am J Gastroenterol. 2003;98:1228–1236
  52. Mariani G, Boni G, Barreca M, et al. Radionuclide gastroesophageal motor studies. J Nucl Med. 2004;45:1004–1028
  53. Bredenoord AJ, Chial HJ, Camilleri M, et al. Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms. Clin Gastroenterol Hepatol. 2003;1:264–272

PII: S0002-9610(06)00716-1

doi: 10.1016/j.amjsurg.2006.10.013

The American Journal of Surgery
Volume 193, Issue 2 , Pages 200-205 , February 2007