The American Journal of Surgery
Volume 193, Issue 3 , Pages 345-348 , March 2007

The effect of methylprednisolone on warm ischemia-reperfusion injury in the liver

Presented at the 49th Annual Meeting of the Midwest Surgical Association, Mackinac Island, MI, August 6–9, 2006

  • Reza F. Saidi, M.D.

      Affiliations

    • Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI, USA
    • ,
  • Jennifer Chang, M.D.

      Affiliations

    • Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI, USA
    • ,
  • Steve Verb, M.D.

      Affiliations

    • Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI, USA
    • ,
  • Steve Brooks, M.D.

      Affiliations

    • Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI, USA
    • ,
  • Ilke Nalbantoglu, M.D.

      Affiliations

    • Department of Pathology, St John Hospital and Medical Center, Detroit, MI, USA
    • ,
  • Volkan Adsay, M.D.

      Affiliations

    • Department of Pathology, Wayne State University, Detroit, MI, USA
    • ,
  • Michael J. Jacobs, M.D., F.A.C.S.

      Affiliations

    • Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI, USA
    • Corresponding Author InformationCorresponding author. 22250 Providence Dr., Suite 700, Southfield, MI 48075. Tel: +1-248-559-5115; fax: +1-248-559-5336.

Received 12 August 2006 ,Revised 20 September 2006

References 

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  2. Belghiti J, Noun R, Zante E, et al. Portal triad clamping or hepatic vascular exclusion for major liver resection (A controlled study). Ann Surg. 1996;224:155–161
  3. Cunningham JD, Fong Y, Shriver C, et al. One hundred consecutive hepatic resections (Blood loss, transfusion, and operative technique). Arch Surg. 1994;129:1050–1056
  4. Bismuth H, Castaing D, Garden OJ. Major hepatic resection under total vascular exclusion. Ann Surg. 1989;210:13–19
  5. Clavien PA, Yadav S, Sindram D, et al. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Ann Surg. 2000;232:155–162
  6. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg. 2001;181:160–166
  7. Vollmar B, Glasz J, Leiderer R, et al. Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol. 1994;145:1421–1431
  8. Colletti LM, Kunkel SL, Walz A, et al. The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology. 1996;23:506–514
  9. Shirasugi N, Wakabayashi G, Shimazu M, et al. Up-regulation of oxygen-derived free radicals by interleukin-1 in hepatic ischemia/reperfusion injury. Transplantation. 1997;64:1398–1403
  10. Shito M, Wakabayashi G, Ueda M, et al. Interleukin 1 receptor blockade reduces tumor necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. Transplantation. 1997;63:143–148
  11. Suzuki S, Toledo-Pereyra LH. Interleukin 1 and tumor necrosis factor production as the initial stimulants of liver ischemia and reperfusion injury. J Surg Res. 1994;57:253–258
  12. Hill GE, Alonso A, Spurzem JR, et al. Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans. J Thorac Cardiovasc Surg. 1995;110:1658–1662
  13. Wan S, DeSmet JM, Antoine M, et al. Steroid administration in heart and heart-lung transplantation: is the timing adequate?. Ann Thorac Surg. 1996;61:674–678
  14. Jansen NJ, van Oeveren W, van den Broek L, et al. Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1991;102:515–525
  15. Eidelman Y, Glat PM, Pachter HL, et al. The effects of topical hypothermia and steroids on ATP levels in an in vivo liver ischemia model. J Trauma. 1994;37:677–681
  16. Figueroa I, Santiago-Delpin EA. Steroid protection of the liver during experimental ischemia. Surg Gynecol Obstet. 1975;140:368–370
  17. Sileri P, Schena S, Fukada J, et al. Corticosteroids enhance hepatic injury following ischemia-reperfusion. Transplant Proc. 2001;33:3712
  18. Bilbao G, Contreras JL, Eckhoff DE, et al. Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene. Ann Surg. 1999;230:185–193

PII: S0002-9610(06)00795-1

doi: 10.1016/j.amjsurg.2006.09.017

The American Journal of Surgery
Volume 193, Issue 3 , Pages 345-348 , March 2007

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