Surgical treatment of pancreatic endocrine neoplasms

Gomez-Rivera, Fernando; Stewart, Ashley E.; Arnoletti, J. Pablo; Vickers, Selwyn; Bland, Kirby I.; Heslin, Martin J.

doi:10.1016/j.amjsurg.2006.10.016

« Previous Next »The American Journal of Surgery
Volume 193, Issue 4 , Pages 460-465, April 2007

Surgical treatment of pancreatic endocrine neoplasms

Fernando Gomez-Rivera, M.D.
- Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, 1922 7^th Avenue South, Room 321, Birmingham, AL, USA
Ashley E. Stewart, M.D.
- Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, 1922 7^th Avenue South, Room 321, Birmingham, AL, USA
J. Pablo Arnoletti, M.D.
- Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, 1922 7^th Avenue South, Room 321, Birmingham, AL, USA
Selwyn Vickers, M.D.
- Section of Gastrointestinal Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
Kirby I. Bland, M.D.
- Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, 1922 7^th Avenue South, Room 321, Birmingham, AL, USA
Martin J. Heslin, M.D.
- Section of Surgical Oncology, Department of Surgery, University of Alabama at Birmingham, 1922 7^th Avenue South, Room 321, Birmingham, AL, USA
- Corresponding author. Department of Surgery, Section of Surgical Oncology, University of Alabama at Birmingham, 321 Kracke Building, 1922 7th Ave. S., Birmingham, AL 35294. Tel.: (205) 934-3064; fax: (205) 975-5971.

Received 24 July 2006; received in revised form 16 October 2006

Abstract

Background

Pancreatic endocrine neoplasia (PEN) is an entity with an indolent course and prolonged survival. The aim of the current study was to review the prognostic factors and outcome of patients with PEN at 1 institution.

Methods

Records of patients with the diagnosis of PEN in the period of 1980 to 2001 were reviewed. Descriptive statistics and log-rank test were used; significance was defined as P < .05.

Results

Of 49 patients, 25 had functional and 24 nonfunctional tumors. Surgery was performed in 43 patients, 36 with curative intent. With a median follow-up of 31 months, there were 5 deaths. Symptoms were controlled with surgical resection in 86%. Median disease-free survival (DFS) was 46 months; actuarial 5-year disease-specific (DSS) was 72%. Factors associated with better DFS and DSS were absence of liver involvement (P = .02) and resection of the primary tumor (P = .04).