The American Journal of Surgery
Volume 193, Issue 5 , Pages 547-550 , May 2007

Prognostic significance of reactivation of telomerase in breast core biopsy specimens

Presented at the 93rd Annual Meeting of the North Pacific Surgical Association, Spokane, WA, November 10–11, 2006

  • Garth S. Herbert, M.D.

      Affiliations

    • Department of Surgery, Madigan Army Medical Center, 9040A Reid St, Tacoma, WA 98431, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-253-968-2200; fax: +1-253-968-5900.
    • ,
  • Vance Y. Sohn, M.D.

      Affiliations

    • Department of Surgery, Madigan Army Medical Center, 9040A Reid St, Tacoma, WA 98431, USA
    • ,
  • Michael J. Mulcahy, M.D.

      Affiliations

    • Department of Surgery, Madigan Army Medical Center, 9040A Reid St, Tacoma, WA 98431, USA
    • ,
  • Anne L. Champeaux, M.D.

      Affiliations

    • Department of Pathology, Madigan Army Medical Center, Tacoma, WA 98431, USA
    • ,
  • Tommy A. Brown, M.D.

      Affiliations

    • Department of Surgery, Madigan Army Medical Center, 9040A Reid St, Tacoma, WA 98431, USA

Received 6 December 2006 ,Revised 29 January 2007

References 

  1. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266:2011–2015
  2. Artandi SE. Telomeres, telomerase, and human disease. N Engl J Med. 2006;355:1195–1197
  3. Brown TA, Wall JW, Christensen ED, et al. Atypical hyperplasia in the era of stereotactic core needle biopsy. J Surg Oncol. 1998;67:168–173
  4. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer. 1997;33:787–791
  5. Song M, Mi X, Li B, et al. Expression of telomerase genes in cancer development in atypical hyperplasia of the mammary duct. Chin Med J (Engl). 2002;115:1221–1225
  6. Mokbel K, Parris CN, Ghilchik M, Williams G, Newbold RF. The association between telomerase, histopathological parameters, and KI-67 expression in breast cancer. Am J Surg. 1999;178:69–72
  7. Poremba C, Shroyer KR, Frost M, et al. Telomerase is a highly sensitive and specific molecular marker in fine-needle aspirates of breast lesions. J Clin Oncol. 1999;17:2020–2026
  8. Elkak AE, Meligonis G, Salhab M, et al. hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer. J Carcinog. 2005;4:17–22
  9. Yan P, Benhattar J, Seelentag W, Stehle JC, Bosman FT. Immunohistochemical localization of hTERT protein in human tissues. Histochem Cell Biol. 2004;121:391–397
  10. Poremba C, Bocker W, Willenbring H, et al. Telomerase activity in human proliferative breast lesions. Int J Oncol. 1998;12:641–648
  11. Renshaw AA, Cartagena N, Schenkman RH, Derhagopian RP, Gould EW. Atypical ductal hyperplasia in breast core needle biopsies (Correlation of size of the lesion, complete removal of the lesion, and the incidence of carcinoma in follow-up biopsies). Am J Clin Pathol. 2001;116:92–96
  12. Moore MM, Hargett CW, Hanks JB, et al. Association of breast cancer with the finding of atypical ductal hyperplasia at core breast biopsy. Ann Surg. 1997;225:726–731discussion 731–33
  13. Lin PH, Clyde JC, Bates DM, Garcia JM, Matsumoto GH, Girvin GW. Accuracy of stereotactic core-needle breast biopsy in atypical ductal hyperplasia. Am J Surg. 1998;175:380–382
  14. Liberman L, Cohen MA, Dershaw DD, Abramson AF, Hann LE, Rosen PP. Atypical ductal hyperplasia diagnosed at stereotaxic core biopsy of breast lesions: an indication for surgical biopsy. AJR Am J Roentgenol. 1995;164:1111–1113
  15. Gadzala DE, Cederbom GJ, Bolton JS, et al. Appropriate management of atypical ductal hyperplasia diagnosed by stereotactic core needle breast biopsy. Ann Surg Oncol. 1997;4:283–286
  16. Pinder SE, Ellis IO. The diagnosis and management of pre-invasive breast disease: ductal carcinoma in situ (DCIS) and atypical ductal hyperplasia (ADH)—current definitions and classification. Breast Cancer Res. 2003;5:254–257
  17. Hiyama E, Hiyama K, Yokoyama T, Shay JW. Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues. Neoplasia. 2001;3:17–26
  18. Darling ML, Smith DN, Lester SC, et al. Atypical ductal hyperplasia and ductal carcinoma in situ as revealed by large-core needle breast biopsy: results of surgical excision. AJR Am J Roentgenol. 2000;175:1341–1346
  19. Hahn WC. Role of telomeres and telomerase in the pathogenesis of human cancer. J Clin Oncol. 2003;21:2034–2043

 This manuscript represents the opinions of the authors alone and does not represent the views of the Department of Defense, the United States Army, or Madigan Army Medical Center.

PII: S0002-9610(07)00061-X

doi: 10.1016/j.amjsurg.2007.01.011

The American Journal of Surgery
Volume 193, Issue 5 , Pages 547-550 , May 2007

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