The American Journal of Surgery
Volume 193, Issue 6 , Pages 676-680 , June 2007

Interleukin-18 restores immune suppression in patients with nonseptic surgery, but not with sepsis

  • Shuhichi Hiraki, M.D.

      Affiliations

    • Department of Surgery, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan
    • ,
  • Satoshi Ono, M.D.

      Affiliations

    • Department of Surgery, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-4-2995-1511; fax: +81-4-2996-5205.
    • ,
  • Manabu Kinoshita, M.D.

      Affiliations

    • Division of Basic Traumatology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan
    • ,
  • Hironori Tsujimoto, M.D.

      Affiliations

    • Department of Surgery, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan
    • ,
  • Shuhji Seki, M.D.

      Affiliations

    • Department of Microbiology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan
    • ,
  • Hidetaka Mochizuki, M.D.

      Affiliations

    • Department of Surgery, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan

Received 15 September 2006 ,Revised 4 October 2006

References 

  1. Ogawa K, Hirai M, Katsube T, et al. Suppression of cellular immunity by surgical stress. Surgery. 2000;127:329–336
  2. Seki S, Osada S, Ono S, et al. Role of liver NK cells and peritoneal macrophages in gamma interferon and IL-10 production in experimental bacterial peritonitis in mice. Infect Immun. 1998;66:5286–5294
  3. Seki S, Habu Y, Kawamura T, et al. The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses. Immunol Rev. 2000;174:35–46
  4. Kinoshita M, Seki S, Ono S, et al. Paradoxical effect of IL-18 therapy on the severe and mild Escherichia coli infections in burn-injured mice. Ann Surg. 2004;240:313–320
  5. Peter FW, Schuschke DA, Barker JH, et al. The effects of severe burn injury on proinflammatory cytokines and leukocyte behavior: its modulation with granulocyte colony-stimulating factor. Burns. 1999;25:477–486
  6. Toliver-Kinsky TE, Varma TK, Lin CY, et al. Interferon-gamma production is suppressed in thermally injured mice: decreased production of regulatory cytokines and corresponding receptors. Shock. 2002;18:322–330
  7. Murphey ED, Lin CY, McGuire RW, et al. Diminished bacterial clearance is associated with decreased IL-12 and interferon-gamma production but a sustained proinflammatory response in a murine model of postseptic immunosuppression. Shock. 2004;21:415–425
  8. Zantl N, Uebe A, Neumann B, et al. Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis. Infect Immun. 1998;66:2300–2309
  9. Qiu G, Wang C, Smith R, et al. Role of IFN gamma in bacterial containment in a model of intra-abdominal sepsis. Shock. 2001;16:425–429
  10. Mosmann TR, Morre KW. The role of IL-10 in cross-regulation of Th1 and Th2 responses. Immunol Today. 1991;12:A49–A53
  11. Livingston D, Loder PA, Kramer SM, et al. Interferon gamma administration increases monocyte HLA-DR antigen expression but not endogenous interferon production. Arch Surg. 1994;129:172–178
  12. Okamura H, Tsutsui T, Komatsu M, et al. Cloning of a new cytokine that induces IFN gamma production by T cells. Nature. 1995;378:88–91
  13. Lauwerys BR, Renauld JC, Houssiau FA. Synergistic proliferation and activation of natural killer cells by interleukin 12 and interleukin 18. Cytokine. 1999;11:822–830
  14. Fehniger TA, Yu H, Cooper MA, et al. Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN gamma production in vivo. J Immunol. 2000;164:1643–1647
  15. Tominaga K, Yoshimoto T, Torigoe K, et al. IL-12 synergizes with IL-18 or IL-1beta for IFN gamma production from human T cells. Int Immunol. 2000;12:151–160
  16. Ikuta S, Ono S, Kinoshita M, et al. Interleukin-18 concentrations in the peritoneal fluid correlates with the severity of peritonitis. Am J Surg. 2003;185:550–555
  17. Emmanuilidis K, Weighardt H, Matevossian E, et al. Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: high serum IL-18 as an early predictive indicator of lethal outcome. Shock. 2002;18:301–305
  18. Takabayashi A, Kanai M, Kawai Y, et al. Change in mitochondrial membrane potential in peripheral blood lymphocytes, especially in natural killer cells, is a possible marker for surgical stress on the immune system. World J Surg. 2003;27:659–665

PII: S0002-9610(07)00194-8

doi: 10.1016/j.amjsurg.2006.10.021

The American Journal of Surgery
Volume 193, Issue 6 , Pages 676-680 , June 2007

Article Tools

* Image Usage & Resolution