The American Journal of Surgery
Volume 194, Issue 1 , Pages 35-39 , July 2007

Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis

  • Alexander Novotny, M.D.

      Affiliations

    • Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-89-4140-2034; fax: +49-89-4140-6605.
    • ,
  • Klaus Emmanuel, M.D.

      Affiliations

    • Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany
    • ,
  • Edouard Matevossian, M.D.

      Affiliations

    • Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany
    • ,
  • Monika Kriner, Ph.D.

      Affiliations

    • Institute of Medical Statistics and Epidemiology, Technische Universität, Trogerstr. 7, 81675 Munich, Germany
    • ,
  • Kurt Ulm, Ph.D.

      Affiliations

    • Institute of Medical Statistics and Epidemiology, Technische Universität, Trogerstr. 7, 81675 Munich, Germany
    • ,
  • Holger Bartels, M.D.

      Affiliations

    • Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany
    • ,
  • Bernhard Holzmann, M.D.

      Affiliations

    • Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany
    • ,
  • Heike Weighardt, Ph.D.

      Affiliations

    • Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany
    • H.W. and J.-R.S contributed equally to this work.
    • ,
  • Jörg-Rüdiger Siewert, M.D.

      Affiliations

    • Department of Surgery, Klinikum rechts der Isar, Technische Universität, Ismaninger Str. 22, 81675 Munich, Germany
    • H.W. and J.-R.S contributed equally to this work.

Received 18 March 2006 ,Revised 4 October 2006

References 

  1. Emmanuel K, Weighardt H, Bartels H, et al. Current and future concepts of abdominal sepsis. World J Surg. 2005;29:3–9
  2. Novotny A, Emmanuel K, Bartels H, et al. Indicators for early prediction of outcome in sepsis. Chirurg. 2005;76:837–844
  3. Oberholzer A, Souza SM, Tschoeke SK, et al. Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock. 2005;23:488–493
  4. Meisner M. Biomarkers of sepsis: clinically useful?. Curr Opin Crit Care. 2005;11:473–480
  5. Wittmann DH. Symposium of intra-abdominal infections: introduction. World J Surg. 1990;14:145–230
  6. Wittmann DH, Schein M, Condon RE. Management of secondary peritonitis. Ann Surg. 1996;224:10–18
  7. Wunder C, Eichelbronner O, Roewer N. Are IL-6, IL-10 and PCT plasma concentrations reliable for outcome prediction in severe sepsis? (A comparison with APACHE III and SAPS II). Inflamm Res. 2004;53:158–163
  8. Bone RC, Balk RA, Cerra FB, et al. The ACCP/SCCM Consensus Conference Committee American College of Chest Physicians/Society of Critical Care Medicine Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992;101:1644–1655
  9. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829
  10. Oberhoffer M, Vogelsang H, Russwurm S, et al. Outcome prediction by traditional and new markers of inflammation in patients with sepsis. Clin Chem Lab Med. 1999;37:363–368
  11. Harbarth S, Holeckova K, Froidevaux C, et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med. 2001;164:396–402
  12. Reinhart K, Bayer O, Brunkhorst F, et al. Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med. 2002;30:S302–S312
  13. Haupt W, Riese J, Mehler C, et al. Monocyte function before and after surgical trauma. Dig Surg. 1998;15:102–104
  14. Maruna P, Gurlich R, Frasko R, et al. Cytokines and soluble cytokine receptors in the perioperative period. Sborník Lékařský. 2002;103:273–282
  15. Assicot M, Gendrel D, Carsin H, et al. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993;341:515–518
  16. de Werra I, Jaccard C, Corradin SB, et al. Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med. 1997;25:607–613
  17. Bertsch T, Richter A, Hofheinz H, et al. Procalcitonin (A new marker for acute phase reaction in acute pancreatitis). Langenbecks Arch Chir. 1997;382:367–372

PII: S0002-9610(07)00239-5

doi: 10.1016/j.amjsurg.2006.10.026

The American Journal of Surgery
Volume 194, Issue 1 , Pages 35-39 , July 2007

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