The American Journal of Surgery
Volume 194, Issue 1 , Pages 53-56 , July 2007

Mediastinal hyperfunctioning parathyroids: incidence, evolving treatment, and outcome

Presented at the 49th Annual Meeting of the Midwest Surgical Association, Mackinac Island, MI, August 5–9, 2006

  • Naris Nilubol, M.D.

      Affiliations

    • Department of Surgery, Rush University Medical Center, 1725 W. Harrison Street, Ste. 818, Chicago, IL 60612, USA
    • ,
  • Todd Beyer, M.D.

      Affiliations

    • Department of Surgery, Rush University Medical Center, 1725 W. Harrison Street, Ste. 818, Chicago, IL 60612, USA
    • ,
  • Richard A. Prinz, M.D.

      Affiliations

    • Department of Surgery, Rush University Medical Center, 1725 W. Harrison Street, Ste. 818, Chicago, IL 60612, USA
    • ,
  • Carmen C. Solorzano, M.D.

      Affiliations

    • Department of Surgery, Rush University Medical Center, 1725 W. Harrison Street, Ste. 818, Chicago, IL 60612, USA
    • Department of Surgery, University of Miami, 1475 NW 12th Ave., Room 3550, Miami, FL 33136, USA
    • Corresponding Author InformationCorresponding author. Sylvester Comprehensive Cancer Center, Department of Surgery (M-875), 1475 N.W. 12th Ave, Room 3550, Miami, FL 33136. Tel.: +1-305-243-4211 (ext. 3); fax: +1-305-243-4221.

Received 14 August 2006 ,Revised 6 November 2006

References 

  1. Cope O. The story of hyperparathyroidism at the Massachusetts General Hospital. N Engl J Med. 1966;274:1174–1182
  2. Nathaniels EK, Nathaniels AM, Wang C. Mediastinal parathyroid tumors: a clinical and pathological study of 84 cases. Ann Surg. 1970;171:165–170
  3. O’Herrin J, Weigel T, Wilson M, et al. Radioguided parathryoidectomy via VATS combined with intraoperative parathyroid hormone testing: the surgical approach of choice for patients with mediastinal parathyroid adenomas?. J Bone Miner Res. 2002;17:1368–1371
  4. Clark OH. Mediastinal parathyroid tumors. Arch Surg. 1988;123:1096–1100
  5. Russell CF, Edis AJ, Scholz DA, et al. Mediastinal parathyroid tumors: experience with 38 tumors requiring mediastinostomy for removal. Ann Surg. 1981;193:805–809
  6. Ipponsugi S, Takamori S, Suga K, et al. Mediastinal parathyroid adenoma detected by 99mTc-methoxyisobutylisonitrile: report of a case. Jpn J Surg. 1990;20:81–86
  7. Prinz RA, Lonchyna V, Carnaille B, et al. Thoracoscopic excision of enlarged mediastinal parathyroid glands. Surgery. 1994;116:999–1004
  8. Knight R, Ratzer ER, Fenoglio ME, et al. Thoracoscopic excision of mediastinal parathyroid adenomas: a report of two cases and review of the literature. J Am Coll Surg. 1997;185:481–485
  9. Cupisti K, Dotzenrath C, Simon D, et al. Therapy of suspected intrathoracic parathyroid adenomas (Experiences using open transthoracic approach and video-assisted thoracoscopic surgery). Langenbecks Arch Surg. 2002;386:488–493
  10. Conn JM, Goncalves MA, Mansour KA, et al. The mediastinal parathyroid. Am Surg. 1991;57:62–66
  11. Medrano C, Hazelrigg SR, Landreneau RJ, et al. Thoracoscopic ressection of ectopic parathyroid glands. Ann Thorac Surg. 2000;69:221–223
  12. Levin KE, Clark OH. The reasons for failure in parathyroid operations. Arch Surg. 1989;124:911–914
  13. Nwariaku FE, Snyder WH, Burkey SH, et al. Inframanubrial parathyroid glands in patients with primay HPT. World J Surg. 2005;29:491–494
  14. Krausz Y, Bettman L, Guralnik L, et al. Technetium-99m-MIBI SPECT/CT in primary hyperparathyroidism. World J Surg. 2006;30:76–83
  15. Wild JL, Weigel T, Chen H. The need for intraoperative parathyroid hormone monitoring during radioguided parathyroidectomy by video-assisted thoracoscopy (VATS). Clin Nucl Med. 2006;31:9–12
  16. Arnalsteen L, Quievreux JL, Huglo D, et al. [Reoperation for persistent or recurrent primary hyperparathyroidism. Seventy-seven cases among 1888 operated patients.]. ] Ann Chir. 2004;129:224–231
  17. Freeman JB, Sherman BM, Mason EE. Transcervical thymectomy. Arch Surg. 1975;111:359–364
  18. Roslyn JJ, Gordon HE, Mulder DG. Mediastinal parathyroid adenomas (A cause of persistent hyperparathyroidism). Am Surg. 1983;49:523–527
  19. Conn JM, Goncalves MA, Mansour KA, et al. The mediastinal parathyroid. Am Surg. 1991;57:62–66
  20. Medrano C, Hazelrigg SR, Landreneau RJ, et al. Thoracoscopic resection of ectopic parathyroid glands. Ann Thorac Surg. 2000;69:221–223
  21. Kao CL, Chau FF, Chang JP. Minimal invasive surgery for resection of parathyroid tumor in the aortopulmonary window. J Cardiovasc Surg. 2003;44:139–141
  22. Yoshida T, Nagahama T, Maruyama M, et al. Thoracoscopically managed parathyroid adenoma in the upper anterior mediastinum. Surg Laparosc Endosc Percutan Tech. 2001;6:385–388
  23. Quiros RM, Warren W, Prinz RA. Excision of a mediastinal parathyroid gland with use of video-assisted thoracoscopy, intraoperative 99mTc-sestamibi scanning, and intraoperative monitoring of intact parathyroid hormone. Endocr Pract. 2004;10:45–48
  24. Ott MC, Malthaner RA, Reid R. Intraoperative radioguided thoracoscopic removal of ectopic parathyroid adenoma. Ann Thorac Surg. 2001;72:1758–1760
  25. Weigel TL, Murphy J, Kabbani L, et al. Radioguided thoracoscopic mediastinal parathyroidectomy with intraoperative parathyroid hormone testing. Ann Thorac Surg. 2005;80:1262–1265
  26. Moe SM, Chertow GM, Coburn JW, et al. Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl. Kidney Int. 2005;67:760–771
  27. Peacock M, Bilezikian JP, Klassen PS, et al. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2005;90:135–141

PII: S0002-9610(07)00243-7

doi: 10.1016/j.amjsurg.2006.11.019

The American Journal of Surgery
Volume 194, Issue 1 , Pages 53-56 , July 2007

Article Tools

* Image Usage & Resolution