Tumor size is a major determinant of recurrence in patients with resectable gastrointestinal stromal tumor

Hsu, Kai-Hsi; Yang, Ta-Ming; Shan, Yan-Shen; Lin, Pin-Wen

doi:10.1016/j.amjsurg.2006.10.033

« Previous Next »The American Journal of Surgery
Volume 194, Issue 2 , Pages 148-152, August 2007

Tumor size is a major determinant of recurrence in patients with resectable gastrointestinal stromal tumor

Kai-Hsi Hsu, M.D.
- Department of Surgery, Tainan Hospital, Department of Health, Executive Yuan, 125, Jhong-Shan Rd, Tainan 700, Taiwan, ROC
- Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, 138, Sheng-Li Rd, Tainan 70428, Taiwan, ROC
Ta-Ming Yang, M.D.
- Department of Surgery, Tainan Municipal Hospital, 670, Chung-Te Rd, Tainan 701, Taiwan, ROC
Yan-Shen Shan, M.D., Ph.D.
- Department of Surgery, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 138, Sheng-Li Rd., Tainan 70428, Taiwan, ROC
- Corresponding author. Tel.: +011-886-6-2353535-5182; fax: +011-886-6-276-6676.
Pin-Wen Lin, M.D.
- Department of Surgery, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, 138, Sheng-Li Rd., Tainan 70428, Taiwan, ROC

Received 5 May 2006; received in revised form 3 October 2006

Abstract

Background

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the mainstay of curative treatment. Recurrence after surgery was frequent and was associated with poor prognosis. In this study, we tried to identify predictors of recurrence in resectable GISTs.

Methods

Between January 1995 and December 2005, 100 patients undergoing surgical resection for GISTs in 2 hospitals were studied.

Results

There were 67 gastric and 33 intestinal GISTs. Recurrence was noted in 11 patients (median follow-up of 43 months). Overall 5-year survival was 84%. Multivariate analysis demonstrated that tumor size ≥10 cm was associated with higher recurrence rates (P = .032) and was the only independent poor prognostic factor for survival (P = .020).

Conclusions

We concluded that tumor size ≥10 cm carried both a higher risk of recurrence and worse survival in resectable GISTs and could be considered an indicator for adjuvant therapy.

Keywords: Gastrointestinal stromal tumor, Recurrence, Tumor size