The American Journal of Surgery
Volume 194, Issue 4, Supplement , Pages S39-S44 , October 2007

Outcome determinants in acute pancreatitis

  • Bettina M. Rau, M.D.

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +0049-6841/162-2630; fax: +0049-6841/162-3132.

References 

  1. Bradley EL. A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg. 1993;128:586–590
  2. Leger L, Chiche B, Louvel A. Pancreatic necrosis and acute pancreatitis. World J Surg. 1981;5:315–317
  3. Jimenez H, Aldrete JS. Clinical implications derived from the morphological classification of 89 patients with acute pancreatitis. J Clin Gastroenterol. 1983;5:137–142
  4. Beger HG, Bittner R, Block S, et al. Bacterial contamination of pancreatic necrosis: a prospective clinical study. Gastroenterology. 1986;91:433–438
  5. Kivisaari L, Somer K, Standertskjold-Nordenstam CG, et al. Early detection of acute fulminant pancreatitis by contrast-enhanced computed tomography. Scand J Gastroenterol. 1983;18:39–41
  6. Block S, Maier W, Bittner R, et al. Identification of pancreas necrosis in severe acute pancreatitis: imaging procedures versus clinical staging. Gut. 1986;27:1035–1042
  7. Schroder T, Kivisaari L, Standertskjold-Nordenstam CG, et al. The clinical significance of contrast enhanced computed tomography in acute pancreatitis. Ann Chir Gynaecol. 1984;73:268–272
  8. Uhl W, Warshaw A, Imrie C, et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology. 2002;2:565–573
  9. UK guidelines for the management of acute pancreatitis. Gut. 2005;54(suppl 3):1–9
  10. Isenmann R, Rau B, Beger HG. Bacterial infection and extent of necrosis are determinants of organ failure in patients with acute necrotizing pancreatitis. Br J Surg. 1999;86:1020–1024
  11. Buchler MW, Gloor B, Muller CA, et al. Acute necrotizing pancreatitis: treatment strategy according to the status of infection. Ann Surg. 2000;232:619–626
  12. Gotzinger P, Sautner T, Kriwanek S, et al. Surgical treatment for severe acute pancreatitis: extent and surgical control of necrosis determine outcome. World J Surg. 2002;26:474–478
  13. Bradley EL. Operative vs non-operative management in sterile necrotizing pancreatitis. HPB Surg. 1997;10:188–191
  14. Guillaumes S, Blanco I, Clave P, et al. Non-operative management of necrosis an acute pancreatitis. Pancreas. 1992;7:740
  15. Waclawiczek HW, Chmelizek F, Heinerman M, et al. [Laparoastoma (open packing) in the treatment concept of infected pancreatic necroses]. Wien Klin Wochenschr. 1992;104:443–447
  16. Manes G, Rabitti PG, Laccetti M, et al. Early prognostic assessment of acute pancreatitis with sterile necrosis: a perspective clinical study. Recenti Prog Med. 1994;85:490–493
  17. Uomo G, Visconti M, Manes G, et al. Nonsurgical treatment of acute necrotizing pancreatitis. Pancreas. 1996;12:142–148
  18. Perez A, Whang EE, Brooks DC, et al. Is severity of necrotizing pancreatitis increased in extended necrosis and infected necrosis?. Pancreas. 2002;25:229–233
  19. Malangoni MA, Martin AS. Outcome of severe acute pancreatitis. Am J Surg. 2005;189:273–277
  20. Rau BM, Bothe A, Kron M, et al. Role of early multisystem organ failure as major risk factor for pancreatic infections and death in severe acute pancreatitis. Clin Gastroenterol Hepatol. 2006;4:1053–1061
  21. Zhu AJ, Shi JS, Sun XJ. Organ failure associated with severe acute pancreatitis. World J Gastroenterol. 2003;9:2570–2573
  22. Kong L, Santiago N, Han TQ, et al. Clinical characteristics and prognostic factors of severe acute pancreatitis. World J Gastroenterol. 2004;10:3336–3338
  23. Gerzof SG, Banks PA, Robbins AH, et al. Early diagnosis of pancreatic infection by computed tomography-guided aspiration. Gastroenterology. 1987;93:1315–1320
  24. Rau B, Bothe A, Beger HG. Surgical treatment of necrotizing pancreatitis by necrosectomy and closed lavage: changing patient characteristics and outcome in a 19-year, single-center series. Surgery. 2005;138:28–39
  25. Runzi M, Niebel W, Goebell H, et al. Severe acute pancreatitis: nonsurgical treatment of infected necroses. Pancreas. 2005;30:195–199
  26. Connor S, Alexakis N, Raraty MG, et al. Early and late complications after pancreatic necrosectomy. Surgery. 2005;137:499–505
  27. Villazon A. Retroperitoneal drainage in the management of the septic phase of severe acute pancreatitis. World J Surg. 1991;15:408–409
  28. Branum G, Galloway J, Hirchowitz W, et al. Pancreatic necrosis: results of necrosectomy, packing, and ultimate closure over drains. Ann Surg. 1998;227:870–877
  29. Oleynikov D, Cook C, Sellers B, et al. Decreased mortality from necrotizing pancreatitis. Am J Surg. 1998;176:648–653
  30. Fernandez-del Castillo C, Rattner DW, Makary MA, et al. Debridement and closed packing for the treatment of necrotizing pancreatitis. Ann Surg. 1998;228:676–684
  31. Bhansali SK, Shah SC, Desai SB, et al. Infected necrosis complicating acute pancreatitis: experience with 131 cases. Indian J Gastroenterol. 2003;22:7–10
  32. Orlando R, Welch JP, Akbari CM, et al. Techniques and complications of open packing of infected pancreatic necrosis. Surg Gynecol Obstet. 1993;177:65–71
  33. Bradley EL. Management of infected pancreatic necrosis by open drainage. Ann Surg. 1987;206:542–550
  34. Fugger R, Gotzinger P, Sautner T, et al. Necrosectomy and laparostomy—a combined therapeutic concept in acute necrotising pancreatitis. Eur J Surg. 1995;161:103–107
  35. Dominioni L, Chiappa A, Bianchi V, et al. Infected pancreatic necrosis complicated by multiple organ failure. Hepatogastroenterology. 1997;44:968–974
  36. Bosscha K, Hulstaert PF, Hennipman A, et al. Fulminant acute pancreatitis and infected necrosis: results of open management of the abdomen and “planned” reoperations. J Am Coll Surg. 1998;187:255–262
  37. Tsiotos GG, Luque-de Leon E, Soreide JA, et al. Management of necrotizing pancreatitis by repeated operative necrosectomy using a zipper technique. Am J Surg. 1998;175:91–98
  38. Radenkovic DV, Bajec DD, Tsiotos GG, et al. Planned staged reoperative necrosectomy using an abdominal zipper in the treatment of necrotizing pancreatitis. Surg Today. 2005;35:833–840
  39. Vesentini S, Bassi C, Talamini G, et al. Prospective comparison of C-reactive protein level, Ranson score and contrast-enhanced computed tomography in the prediction of septic complications of acute pancreatitis. Br J Surg. 1993;80:755–757
  40. De Waele JJ, Hesse UJ, Pattyn P, et al. Postoperative lavage and on demand surgical intervention in the treatment of acute necrotizing pancreatitis. Acta Chir Belg. 2000;100:16–20
  41. Farkas G, Marton J, Mandi Y, et al. Surgical management and complex treatment of infected pancreatic necrosis: 18-year experience at a single center. J Gastrointest Surg. 2006;10:278–285
  42. Gong ZY, Tang YQ. Onset time of complications in patients with severe acute pancreatitis receiving nonoperative therapy. Hepatobiliary Pancreat Dis Int. 2002;1:143–145
  43. Buter A, Imrie CW, Carter CR, et al. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br J Surg. 2002;89:298–302
  44. Johnson CD, Abu-Hilal M. Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut. 2004;53:1340–1344
  45. Mofidi R, Duff MD, Wigmore SJ, et al. Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis. Br J Surg. 2006;93:738–744
  46. Isenmann R, Rau B, Beger HG. Early severe acute pancreatitis: characteristics of a new subgroup. Pancreas. 2001;22:274–278
  47. De Waele JJ, Hoste E, Blot SI, et al. Perioperative factors determine outcome after surgery for severe acute pancreatitis. Crit Care. 2004;8:R504–R511
  48. Leppaniemi A, Kemppainen E. Recent advances in the surgical management of necrotizing pancreatitis. Curr Opin Crit Care. 2005;11:349–352
  49. Tao HQ, Zhang JX, Zou SC. Clinical characteristics and management of patients with early acute severe pancreatitis: experience from a medical center in China. World J Gastroenterol. 2004;10:919–921
  50. De Waele JJ, Hoste E, Blot SI, et al. Intra-abdominal hypertension in patients with severe acute pancreatitis. Crit Care. 2005;9:R452–R457
  51. Poves Prim I, Fabregat Pous J, Garcia Borobia FJ, et al. Early onset of organ failure is the best predictor of mortality in acute pancreatitis. Rev Esp Enferm Dig. 2004;96:705–709
  52. Sun ZX, Huang HR, Zhou H. Indwelling catheter and conservative measures in the treatment of abdominal compartment syndrome in fulminant acute pancreatitis. World J Gastroenterol. 2006;12:5068–5070
  53. Ranson JH, Rifkind KM, Roses DF, et al. Objective early identification of severe acute pancreatitis. Am J Gastroenterol. 1974;61:443–451
  54. Imrie CW, Benjamin IS, Ferguson JC, et al. A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg. 1978;65:337–341
  55. Le Mee J, Paye F, Sauvanet A, et al. Incidence and reversibility of organ failure in the course of sterile or infected necrotizing pancreatitis. Arch Surg. 2001;136:1386–1390
  56. Flint R, Windsor JA. Early physiological response to intensive care as a clinically relevant approach to predicting the outcome in severe acute pancreatitis. Arch Surg. 2004;139:438–443
  57. Satoh A, Miura T, Satoh K, et al. Human leukocyte antigen-DR expression on peripheral monocytes as a predictive marker of sepsis during acute pancreatitis. Pancreas. 2002;25:245–250
  58. Mentula P, Kylanpaa-Back ML, Kemppainen E, et al. Decreased HLA (human leucocyte antigen)-DR expression on peripheral blood monocytes predicts the development of organ failure in patients with acute pancreatitis. Clin Sci (Lond). 2003;105:409–417
  59. Ho YP, Sheen IS, Chiu CT, et al. A strong association between down-regulation of HLA-DR expression and the late mortality in patients with severe acute pancreatitis. Am J Gastroenterol. 2006;101:1117–1124
  60. Kylanpaa ML, Mentula P, Kemppainen E, et al. Monocyte anergy is present in patients with severe acute pancreatitis and is significantly alleviated by granulocyte-macrophage colony-stimulating factor and interferon-gamma in vitro. Pancreas. 2005;31:23–27
  61. Nordback I, Pessi T, Auvinen O, et al. Determination of necrosis in necrotizing pancreatitis. Br J Surg. 1985;72:225–227
  62. Lankisch PG, Schirren CA. Increased body weight as a prognostic parameter for complications in the course of acute pancreatitis. Pancreas. 1990;5:626–629
  63. Martinez J, Johnson CD, Sanchez-Paya J, et al. Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysis. Pancreatology. 2006;6:206–209
  64. de Beaux AC, Palmer KR, Carter DC. Factors influencing morbidity and mortality in acute pancreatitis; an analysis of 279 cases. Gut. 1995;37:121–126
  65. Park J, Fromkes J, Cooperman M. Acute pancreatitis in elderly patients: pathogenesis and outcome. Am J Surg. 1986;152:638–642
  66. Fan ST, Choi TK, Lai EC, et al. Acute pancreatitis in the aged. Aust N Z J Surg. 1988;58:717–721
  67. Paajanen H, Jaakkola M, Oksanen H, et al. Acute pancreatitis in patients over 80 years. Eur J Surg. 1996;162:471–475
  68. McKay CJ, Evans S, Sinclair M, et al. High early mortality rate from acute pancreatitis in Scotland, 1984-1995. Br J Surg. 1999;86:1302–1305
  69. Toh SK, Phillips S, Johnson CD. A prospective audit against national standards of the presentation and management of acute pancreatitis in the South of England. Gut. 2000;46:239–243
  70. Halonen KI, Leppaniemi AK, Puolakkainen PA, et al. Severe acute pancreatitis: prognostic factors in 270 consecutive patients. Pancreas. 2000;21:266–271
  71. Ogawa M, Hirota M, Hayakawa T, et al. Development and use of a new staging system for severe acute pancreatitis based on a nationwide survey in Japan. Pancreas. 2002;25:325–330
  72. Halonen KI, Leppaniemi AK, Lundin JE, et al. Predicting fatal outcome in the early phase of severe acute pancreatitis by using novel prognostic models. Pancreatology. 2003;3:309–315
  73. Company L, Saez J, Martinez J, et al. Factors predicting mortality in severe acute pancreatitis. Pancreatology. 2003;3:144–148
  74. Pearce CB, Gunn SR, Ahmed A, et al. Machine learning can improve prediction of severity in acute pancreatitis using admission values of APACHE II score and C-reactive protein. Pancreatology. 2006;6:123–131
  75. Brisinda G, Maria G, Ferrante A, et al. Evaluation of prognostic factors in patients with acute pancreatitis. Hepatogastroenterology. 1999;46:1990–1997
  76. Blum T, Maisonneuve P, Lowenfels AB, et al. Fatal outcome in acute pancreatitis: its occurrence and early prediction. Pancreatology. 2001;1:237–241
  77. Sun B, Li HL, Gao Y, et al. Factors predisposing to severe acute pancreatitis: evaluation and prevention. World J Gastroenterol. 2003;9:1102–1105
  78. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829
  79. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383
  80. Rabeneck L, Feinstein AR, Horwitz RI, et al. A new clinical prognostic staging system for acute pancreatitis. Am J Med. 1993;95:61–70
  81. Tran DD, Cuesta MA, Schneider AJ, et al. Prevalence and prediction of multiple organ system failure and mortality in acute pancreatitis. J Crit Care. 1993;8:145–153
  82. Losanoff JE, Asparouhov OK, Jones JW. Multiple factor scoring system for risk assessment of acute pancreatitis. J Surg Res. 2001;101:73–78

PII: S0002-9610(07)00396-0

doi: 10.1016/j.amjsurg.2007.05.019

The American Journal of Surgery
Volume 194, Issue 4, Supplement , Pages S39-S44 , October 2007