The American Journal of Surgery
Volume 194, Issue 4 , Pages 467-473 , October 2007

A device for real-time, intraoperative margin assessment in breast-conservation surgery

Presented at the 8th Annual Meeting of the American Society of Breast Surgeons, Phoenix, AZ, May 2–6, 2007

  • Tami Karni, M.D.

      Affiliations

    • Breast Care Institute, Assaf Harofeh Medical Center, Zrifin Beer Yaakov, 70300, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel
    • Corresponding Author InformationCorresponding author. Tel.: +972-8-977-8195; fax: +972-8-977-8192.
    • ,
  • Itzhak Pappo, M.D.

      Affiliations

    • Breast Care Institute, Assaf Harofeh Medical Center, Zrifin Beer Yaakov, 70300, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel
    • ,
  • Judith Sandbank, M.D.

      Affiliations

    • Department of Pathology, Assaf Harofeh Medical Center, Zrifin, Beer Yaakov, 70300, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel
    • ,
  • Oleg Lavon, M.D.

      Affiliations

    • Department of Pathology, Assaf Harofeh Medical Center, Zrifin, Beer Yaakov, 70300, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel
    • ,
  • Varda Kent, M.D.

      Affiliations

    • Breast Care Institute, Assaf Harofeh Medical Center, Zrifin Beer Yaakov, 70300, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel
    • ,
  • Rona Spector, M.D.

      Affiliations

    • Department of Surgery, Rabin Medical Centers, Beilinson Campus, Petah Tikva, 49100, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel
    • ,
  • Sara Morgenstern, M.D.

      Affiliations

    • Department of Pathology, Rabin Medical Centers, Beilinson Campus, Petah Tikva, 49100, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel
    • ,
  • Shlomo Lelcuk, M.D.

      Affiliations

    • Department of Surgery, Rabin Medical Centers, Beilinson Campus, Petah Tikva, 49100, Israel
    • Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv, 69978, Israel

Received 26 April 2007 ,Revised 26 June 2007

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer Statistics, 2007. CA Cancer J Clin. 2007;57:43–66
  2. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241
  3. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–1232
  4. Jacobson JA, Danforth DN, Cowan KH, et al. Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med. 1995;332:907–911
  5. Arriagada R, Le MG, Rochard F, Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data (Institut Gustave-Roussy Breast Cancer Group). J Clin Oncol. 1996;14:1558–1564
  6. National Comprehensive Cancer Network, Inc. The NCCN Breast Cancer Clinical Practice Guidelines in Oncology (Version 1. 2007, 2006). Available at: http://www.nccn.org. Accessed July 30, 2007.
  7. Singletary SE. Surgical margins in patients with early-stage breast cancer with breast conservation surgery. Am J Surg. 2002;184:383–393
  8. Taghian A, Mohiuddin M, Jagsi R, et al. Current perceptions regarding surgical margin status after breast-conserving therapy: results of a survey. Ann Surg. 2005;241:629–639
  9. Tafra L, Fine R, Whitworth P, et al. Prospective randomized study comparing cryo-assisted and needle-wire localization of ultrasound visible breast tumors. Am J Surg. 2006;192:462–470
  10. Menes TS, Tartter PA, Bleiweiss I, et al. The consequence of multiple re-excisions to obtain clear lumpectomy margins in breast cancer patients. Ann Surg Oncol. 2005;12:1–5
  11. Tafra L, Karni T, Cheng Z, et al. Handheld intraoperative margin assessment device for partial mastectomy specimens. 2006;Paper presented at: 7th Annual Meeting of the American Society of Breast Surgeons; April 5–9; Baltimore, MD.
  12. Karni T, Pappo I, Sandbank J, et al. Intra-operative tissue characterization probe as a potential tool for surgical margin assessment. 2005;Paper presented at: 28th Annual San Antonio Breast Cancer Symposium; December 8–11; San Antonio, TX.

PII: S0002-9610(07)00530-2

doi: 10.1016/j.amjsurg.2007.06.013

The American Journal of Surgery
Volume 194, Issue 4 , Pages 467-473 , October 2007

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