The American Journal of Surgery
Volume 194, Issue 4 , Pages 426-432 , October 2007

Sentinel node staging for breast cancer: intraoperative molecular pathology overcomes conventional histologic sampling errors

Presented at the 8th Annual Meeting of the American Society of Breast Surgeons, Phoenix, AZ, May 2–6, 2007

  • Peter Blumencranz, M.D.

      Affiliations

    • Breast Health Services, Morton Plant Mease Health Care, 303 Pinellas St, Ste. 310, Clearwater, FL 33756, USA
    • ,
  • Pat W. Whitworth, M.D.

      Affiliations

    • Nashville Breast Cancer, 300 20th Avenue North, Suite #401, Nashville, TN 37205, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-615-284-8229; fax: +1-615-284-2026.
    • ,
  • Kenneth Deck, M.D.

      Affiliations

    • South Orange County Surgical Medical Group, 24411 Health Center Dr, Ste. 350, Laguna Hills, CA 92653, USA
    • ,
  • Anne Rosenberg, M.D.

      Affiliations

    • Thomas Jefferson University Hospital, 132 S. 10th St, Philadelphia, PA 19107, USA
    • ,
  • Douglas Reintgen, M.D.

      Affiliations

    • Lakeland Regional Cancer Center, 3525 Lakeland Hills Blvd, Lakeland, FL 33805, USA
    • ,
  • Peter Beitsch, M.D.

      Affiliations

    • Dallas Surgical Group, 5920 Forest Park Rd, Ste. 500, Dallas, TX 75235, USA
    • ,
  • Anees Chagpar, M.D.

      Affiliations

    • James Brown Cancer Center, Department of Surgery, Div. of Surgical Oncology (Box M10), 315 E. Broadway, Ste. 312, Louisville, KY 40202, USA
    • ,
  • Thomas Julian, M.D.

      Affiliations

    • Alleghany Cancer Center, WestPenn Allegheny Health System, 320 E. North Ave, Pittsburgh, PA 15212, USA
    • ,
  • Sukamal Saha, M.D.

      Affiliations

    • McLaren Regional Medical Center, Department of Surgery, 3500 Calkins Rd, Ste. A, Flint, MI 48532, USA
    • ,
  • Eleftherios Mamounas, M.D.

      Affiliations

    • Aultman Hospital, Clinical Trials Department, 2600 6th St, S.W., Canton, OH 44710, USA
    • ,
  • Armando Giuliano, M.D.

      Affiliations

    • John Wayne Cancer Institute, 2200 Santa Monica Blvd, Ste. 113, Santa Monica, CA 90404, USA
    • ,
  • Rache Simmons, M.D.

      Affiliations

    • Weill-Cornell Breast Center, 425 E. 61st St, 8th Floor, New York, NY 10021, USA

Received 2 May 2007 ,Revised 3 July 2007

References 

  1. Creager AJ, Geisinger KR. Intraoperative evaluation of sentinel lymph nodes for breast carcinoma: current methodologies. Adv Anat Pathol. 2002;94:3016–3022
  2. Creager AJ, Geisinger KR, Shiver SA, et al. Intraoperative evaluation of sentinel lymph nodes for metastatic breast carcinoma by imprint cytology. Mod Pathol. 2002;15:1140–1147
  3. Treseler PA, Tauchi PS. Pathologic analysis of the sentinel lymph node. Surg Clin North Am. 2000;80:1695–1719
  4. Viale G, Bosari S, Maxxarol G, et al. Intraoperative examination of axillary sentinel lymph nodes in breast carcinoma patients. Cancer. 1999;85:2433–2438
  5. Cserni G. Complete sectioning of axillary sentinel nodes in patients with breast cancer (Analysis of two different step sectioning and immunohistochemistry protocols in 246 patients). J Clin Pathol. 2002;55:926–931
  6. Van Diest PJ, Torrenga H, Meijer S, et al. Pathologic analysis of sentinel lymph nodes. Semin Surg Oncol. 2001;20:238–245
  7. Cserni G. What is a positive sentinel lymph node in a breast cancer patient? (A practical approach). Breast. 2007;16:152–160
  8. American Joint Committee on Cancer (AJCC). Cancer Staging Handbook. In: 6th ed.. New York: Springer-Verlag; 2002;
  9. Backus J, Green GA, Xu M, et al. Intraoperative molecular analysis of sentinel lymph nodes for the management of breast cancer surgery. Clin Cancer Res (in press).
  10. Blumencranz P, Deck KB, Whitworth PW, et al. Abstracts and case studies from the College of American Pathologists 2006 Annual Meeting (CAP 2006). Arch Pathol Lab Med. 2006;130:1362–1403.
  11. Querzoli P, Pedriali M, Rinaldi R, et al. Axillary lymph node nanometastases are prognostic factors for disease-free survival and metastatic relapse in breast cancer patients. Clin Cancer Res. 2006;12:6696–6701
  12. Yared M, Middleton L, Smith T, et al. Recommendations for sentinel lymph node processing in breast cancer. Am J Surg Pathol. 2002;26:377–382
  13. Cserni G. Metastases in axillary sentinel lymph nodes in breast cancer as detected by intensive histopathological workup. J Clin Pathol. 1999;52:922–924
  14. Van Diest PJ, Torrenga H, Borgstein PJ, et al. Reliability of intraoperative frozen section and imprint cytological investigation of sentinel lymph nodes in breast cancer. Histopathology. 1999;35:14–18
  15. Schwartz GF, Giuliano AE, Veronesi U Consensus Conference Committee. Proceedings of the Consensus Conference on the Role of Sentinel Lymph Node Biopsy in Carcinoma of the Breast. 2001;April 19-22, Philadelphia, PA.
  16. Farshid G, Pradhan M, Kollias J, Grantley G. Computer simulations of lymph node metastasis for optimizing the pathologic examination of sentinel lymph nodes in patients with breast carcinoma. Cancer. 2000;89:2527–2537
  17. Cao W, Backus J, Vargo J, et al. Additional markers support results in a molecular breast sentinel lymph node diagnostic assay. Breast Cancer Res Treat. 2006;100(suppl 1):S1–S299
  18. Houghton RL, Dillon DC, Molesh DA, et al. Transcriptional complementarity in breast cancer: application to detection of circulating tumor cells. Mol Diagn. 2001;6:79–91
  19. Zehentner BK, Carter D. Mammaglobin: a candidate diagnostic marker for breast cancer. Clin Biochem. 2004;37:249–257
  20. Backus J, Laughlin T, Wang Y, et al. Identification and characterization of optimal gene expression markers for detection of breast cancer metastasis. J Mol Diagn. 2005;7:327–336

PII: S0002-9610(07)00552-1

doi: 10.1016/j.amjsurg.2007.07.008

The American Journal of Surgery
Volume 194, Issue 4 , Pages 426-432 , October 2007

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