The American Journal of Surgery
Volume 195, Issue 3 , Pages 298-303 , March 2008

Intermediate-term outcomes of hepatitis C-positive compared with hepatitis C-negative deceased-donor renal allograft recipients

  • Kristian L. Brown, M.D.

      Affiliations

    • Section of Transplant Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Jose M. El-Amm, M.D.

      Affiliations

    • Division of Nephrology, Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Mona D. Doshi, M.D.

      Affiliations

    • Division of Nephrology, Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Atul Singh, M.D.

      Affiliations

    • Division of Nephrology, Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Katherina Morawski, R.N.

      Affiliations

    • Section of Transplant Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Elizabeth Cincotta, Pharm.D.

      Affiliations

    • Department of Pharmacy, Harper University Hospital, Detroit, MI 48201, USA
    • ,
  • Firdous Siddiqui, M.D.

      Affiliations

    • Division of Gastroenterology, Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Julian E. Losanoff, M.D.

      Affiliations

    • Section of Transplant Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Miguel S. West, M.D., F.A.C.S.

      Affiliations

    • Section of Transplant Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • ,
  • Scott A. Gruber, M.D., Ph.D., M.B.A., F.A.C.S.

      Affiliations

    • Section of Transplant Surgery, Department of Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-313-745-7319; fax: +1-313-993-0595.

Received 16 November 2007 ,Revised 4 December 2007

References 

  1. Lin HH, Huang CC, Huang JY, et al. Impact of HCV infection on first cadaveric renal transplantation, a single center experience. Clin Transplant. 2004;18:261–266
  2. Giblin L, Clarkson MR, Conlon PJ, et al. Impaired renal allograft, but not patient survival, in patients with antibodies to hepatitis C virus. Ir J Med Sci. 2004;173:82–84
  3. Sahin GM, Sahin S, Kantarci G, Ergin H. Impact of hepatitis C virus infection on patient and graft survival in kidney transplantation. Transplant Proc. 2006;38:499–501
  4. Bruchfeld A, Wilczek H, Elinder C-G. Hepatitis C infection, time in renal-replacement therapy, and outcome after kidney transplantation. Transplantation. 2004;78:745–750
  5. Fabrizi F, Martin P, Dixit V, et al. Hepatitis C virus antibody status and survival after renal transplantation: meta-analysis of observational studies. Am J Transplant. 2005;5:1452–1461
  6. Pedroso S, Martins L, Fonseca I, et al. Impact of hepatitis C virus on renal transplantation: association with poor survival. Transplant Proc. 2006;38:1890–1894
  7. Ali MK, Light JA, Barhyte DY, et al. Donor hepatitis C virus status does not adversely affect short-term outcomes in HCV+ recipients in renal transplantation. Transplantation. 1998;66:1694–1697
  8. Meier-Kriesche HU, Ojo AO, Hanson JA, et al. Hepatitis C antibody status and outcomes in renal transplant recipients. Transplantation. 2001;72:241–244
  9. Mahmoud IM, Elhabashi AF, Elsawy E, et al. The impact of hepatitis C virus viremia on renal graft and patient survival: a 9-year prospective study. Am J Kidney Dis. 2004;43:131–139
  10. Batty DS, Swanson SJ, Kirk AD, et al. Hepatitis C virus seropositivity at the time of renal transplantation in the United States: associated factors and patient survival. Am J Transplant. 2001;1:179–184
  11. Haririan A, Sillix DH, Morawski K, et al. Short-term experience with early steroid withdrawal in African-American renal transplant recipients. Am J Transplant. 2006;6:2396–2402
  12. Akalin E, Murphy B, Sehgal V, et al. Rapid steroid withdrawal in hepatitis C virus-positive kidney transplant recipients. Clin Transplant. 2004;18:384–389
  13. Abbott KC, Bucci JR, Matsumoto CS, et al. Hepatitis C and renal transplantation in the era of modern immunosuppression. J Am Soc Nephrol. 2003;14:2908–2918
  14. Mathurin P, Mouquet C, Poynard T, et al. Impact of hepatitis B and C virus on kidney transplantation outcome. Hepatology. 1999;29:257–263
  15. Hestin D, Guillemin F, Castin N, et al. Pretransplant hepatitis C virus infection: a predictor of proteinuria after renal transplantation. Transplantation. 1998;65:741–744
  16. Foster CE, Philosophe B, Schweitzer EJ, et al. A decade of experience with renal transplantation in African-Americans. Ann Surg. 2002;236:794–804
  17. Shah T, Kasravi A, Huang E, et al. Risk factors for development of new-onset diabetes mellitus after kidney transplantation. Transplantation. 2006;82:1673–1676
  18. Fabrizi F, Martin P, Dixit V, et al. Post-transplant diabetes mellitus and HCV seropositive status after renal transplantation: meta-analysis of clinical studies. Am J Transplant. 2005;5:2433–2440
  19. Lake JR. The role of immunosuppression in recurrence of hepatitis C. Liver Transpl. 2003;9:S63–S66
  20. Gentil MA, López M, González-Roncero F, et al. Hepatitis C and the incidence of diabetes mellitus after renal transplant: influence of new immunosuppression protocols. Transplant Proc. 2003;35:1748–1750

PII: S0002-9610(07)00969-5

doi: 10.1016/j.amjsurg.2007.12.005

The American Journal of Surgery
Volume 195, Issue 3 , Pages 298-303 , March 2008

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