The American Journal of Surgery
Volume 195, Issue 3 , Pages 304-307 , March 2008

Hyperbilirubinemia: a risk factor for infection in the surgical intensive care unit

Received 16 November 2007 ,Revised 7 December 2007

References 

  1. Bansal V, Schuchert VD. Jaundice in the intensive care unit. Surg Clin N Am. 2006;86:1495–1502
  2. Kramer L, Jordan B, Druml W, et al. Incidence and prognosis of early hepatic dysfunction in critically ill patients—a prospective multicenter study. Crit Care Med. 2007;35:1099–1104
  3. Miyaso H, Morimoto Y, Ozaki M, et al. Obstructive jaundice increases sensitivity to lipopolysaccharide via TLR4 upregulation: possible involvement in gut-derived hepatocyte growth factor-protection of hepatocytes. J Gastroenterol Hepatol. 2005;20:1859–1866
  4. Wang WW, Smith DLH, Zucker SD. Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Hepatology. 2004;40:424–433
  5. Sarady-Andrews JK, Lin F, Gallo D, et al. Biliverdin administration protects against endotoxin-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2005;289:L1131–L1137
  6. Overhaus M, Moore BA, Barbato JE, et al. Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators. Am J Physiol Gastrointest Liver Physiol. 2006;290:G695–G703
  7. Keshavan P, Deem TL, Schwemberger SJ, et al. Unconjugated bilirubin inhibits VCAM-1 mediated transendothelial leukocyte migration. J Immunol. 2005;174:3709–3718
  8. Hayashi S, Takamiya R, Yamaguchi T, et al. Induction of heme-oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress. Circ Res. 1999;85:663–671

PII: S0002-9610(07)00979-8

doi: 10.1016/j.amjsurg.2007.12.010

The American Journal of Surgery
Volume 195, Issue 3 , Pages 304-307 , March 2008

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