The American Journal of Surgery
Volume 195, Issue 6 , Pages 770-774 , June 2008

Predictors of re-excision for positive or close margins in breast-conservation therapy for pT1 tumors

  • Rajeev Ramanah, M.D.

      Affiliations

    • Breast Care Unit, Department of Gynaecologic Surgery, Besancon University Hospital, Besancon, France
    • Corresponding Author InformationCorresponding author. Tel.: +011-33 03 81 218 118; fax: +011-33 03 81 218 610.
    • ,
  • Xavier Pivot, M.D., Ph.D.

      Affiliations

    • Department of Oncology, Besancon University Hospital, Besancon, France
    • ,
  • Jean-Loup Sautiere, M.D.

      Affiliations

    • Breast Care Unit, Department of Gynaecologic Surgery, Besancon University Hospital, Besancon, France
    • ,
  • Robert Maillet, M.D.

      Affiliations

    • Breast Care Unit, Department of Gynaecologic Surgery, Besancon University Hospital, Besancon, France
    • ,
  • Didier Riethmuller, M.D., Ph.D.

      Affiliations

    • Breast Care Unit, Department of Gynaecologic Surgery, Besancon University Hospital, Besancon, France

Received 30 January 2007 ,Revised 20 May 2007

References 

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  2. Fisher B, Anderson S, Redmond C, et al. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing to total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1995;333:1456–1461
  3. Van Dongen J, Bartelink H, Fentiman I, et al. Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10801 (Breast conservation compared with mastectomy in TNM stage I and II breast cancer). Eur J Cancer. 1992;28A:801–805
  4. Veronesi U, Salvadori B, Luini A, et al. Breast conservation is a safe method in patients with small cancer of the breast (Long-term results of three randomized trials on 1973 patients). Eur J Cancer. 1995;31A:1574–1579
  5. Jacobson J, Danforth D, Cowan K, et al. Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med. 1995;332:9076
  6. Fisher B, Redmond C, Poisson R, et al. Eight year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1989;320:822–828
  7. Early Breast Cancer Trialists' Collaborative Group. Effect of radiotherapy and surgery in early breast cancer. N Engl J Med. 1995;333:1444–1445
  8. Renton SC, Gazet JC, Ford HT, et al. The importance of resection margin in conservative surgery for breast cancer. Eur J Surg Oncol. 1996;22(1):17–22
  9. Singletary SE. Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. Am J Surg. 2002;184:383–393
  10. Camp ER, McAuliffe PF, Gilroy JS, et al. Minimizing local recurrence after breast conserving therapy using intraoperative shaved margins to determine pathologic tumor clearance. J Am Coll Surg. 2005;6:855–861
  11. Al-Refaie W, Kuerer HM, Khuwaja A, et al. Determinants of mastectomy in breast conservation therapy candidates. Am J Surg. 2005;190:602–605
  12. Mullenix PS, Cuadrado DG, Steele SR, et al. Secondary operations are frequently required to complete the surgical phase of therapy in the era of breast conservation and sentinel lymph node biopsy. Am J Surg. 2004;187:643–646
  13. Keskek M, Kothari M, Ardehali B, et al. Factors predisposing to cavity margin positivity following conservation surgery for breast cancer. Eur J Surg Oncol. 2004;30:1058–1064
  14. Landheer MLEA, Klinkenbijl JHG, Pasker-De Jong PCM, et al. Residual disease after excision of non-palpable breast tumours: analysis of tumour characteristics. Eur J Surg Oncol. 2004;30:824–828
  15. Tartter PI, Kaplan J, Bleiweiss I, et al. Lumpectomy margins, reexcision, and local recurrence of breast cancer. Am J Surg. 2000;179:81–85
  16. Luu HH, Otis CN, Reed SP, et al. The unsatisfactory margin in breast cancer surgery. Am J Surg. 1999;178:362–366
  17. Moorthy K, Asopa V, Wiggins E, et al. Is the reexcision rate higher if breast conservation surgery is performed by surgical trainees?. Am J Surg. 2004;188:45–48
  18. Morrow M. Limiting breast surgery to the proper minimum. Breast. 2005;14:523–526
  19. Dooley WC, Parker J. Understanding the mechanisms of creating false positive lumpectomy margins. Am J Surg. 2005;190:606–608

PII: S0002-9610(08)00088-3

doi: 10.1016/j.amjsurg.2007.05.052

The American Journal of Surgery
Volume 195, Issue 6 , Pages 770-774 , June 2008

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