The American Journal of Surgery
Volume 196, Issue 1 , Pages 13-18 , July 2008

Utility of an intraoperative gamma probe in the surgical management of secondary or tertiary hyperparathyroidism

  • Francisca H. Jorna, M.D.

      Affiliations

    • Department of Surgery/Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • ,
  • Pieter L. Jager, M.D., Ph.D.

      Affiliations

    • Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • ,
  • Clara Lemstra

      Affiliations

    • Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • ,
  • Theo Wiggers, M.D., Ph.D.

      Affiliations

    • Department of Surgery/Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • ,
  • Coen A. Stegeman, M.D., Ph.D.

      Affiliations

    • Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • ,
  • John T.M. Plukker, M.D., Ph.D.

      Affiliations

    • Department of Surgery/Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +0031-50-3612317; fax: +0031-50-3614873.

Received 5 March 2007 ,Revised 23 May 2007

References 

  1. Moe SM, Drueke TB. Management of secondary hyperparathyroidism: the importance and the challenge of controlling parathyroid hormone levels without elevating calcium, phosphorus, and calcium-phosphorus product. Am J Nephrol. 2003;23:369–379
  2. Jorna FH, Tobe TJ, Huisman RM, et al. Early identification of risk factors for refractory secondary hyperparathyroidism in patients with long-term renal replacement therapy. Nephrol Dial Transplant. 2004;19:1168–1173
  3. Dotzenrath C, Cupisti K, Goretzki E, et al. Operative treatment of renal autonomous hyperparathyroidism: cause of persistent or recurrent disease in 304 patients. Langenbecks Arch Surg. 2003;387:348–354
  4. Gasparri G, Camandona M, Abbona GC, et al. Secondary and tertiary hyperparathyroidism: causes of recurrent disease after 446 parathyroidectomies. Ann Surg. 2001;233:65–69
  5. Cattan P, Halimi B, Aidan K, et al. Reoperation for secondary uremic hyperparathyroidism: are technical difficulties influenced by initial surgical procedure?. Surgery. 2000;127:562–565
  6. Goldstein RE, Martin WH, Richards K. Minimally invasive radioguided parathyroidectomy (MIRP). Minerva Chir. 2003;58:269–279
  7. Murphy C, Norman J. The 20% rule: a simple, instantaneous radioactivity measurement defines cure and allows elimination of frozen sections and hormone assays during parathyroidectomy. Surgery. 1999;126:1023–1028
  8. Pons F, Torregrosa JV, Vidal-Sicart S, et al. Preoperative parathyroid gland localization with technetium-99m sestamibi in secondary hyperparathyroidism. Eur J Nucl Med. 1997;24:1494–1498
  9. Pinero A, Rodriguez JM, Ortiz S, et al. Relation of biochemical, cytologic, and morphologic parameters to the result of gammagraphy with technetium 99m sestamibi in primary hyperparathyroidism. Otolaryngol Head Neck Surg. 2000;122:851–855
  10. Olaizola I, Zingraff J, Heuguerot C, et al. [(99m)Tc]-sestamibi parathyroid scintigraphy in chronic haemodialysis patients: static and dynamic explorations. Nephrol Dial Transplant. 2000;15:1201–1206
  11. Piga M, Bolasco P, Satta L, et al. Double phase parathyroid technetium-99m-MIBI scintigraphy to identify functional autonomy in secondary hyperparathyroidism. J Nucl Med. 1996;37:565–569
  12. Denham DW, Norman J. Cost-effectiveness of preoperative sestamibi scan for primary hyperparathyroidism is dependent solely upon the surgeon's choice of operative procedure. J Am Coll Surg. 1998;186:293–305
  13. Malberti F, Marcelli D, Conte F, et al. Parathyroidectomy in patients on renal replacement therapy: an epidemiologic study. J Am Soc Nephrol. 2001;12:1242–1248
  14. Nichol PF, Starling JR, Mack E, et al. Long-term follow-up of patients with tertiary hyperparathyroidism treated by resection of a single or double adenoma. Ann Surg. 2002;235:673–678
  15. Hibi Y, Tominaga Y, Sato T, et al. Reoperation for renal hyperparathyroidism. World J Surg. 2002;26:1301–1307
  16. Chou FF, Lee CH, Chen HY, et al. Persistent and recurrent hyperparathyroidism after total parathyroidectomy with autotransplantation. Ann Surg. 2002;235:99–104
  17. LiVolsi VA, Hamilton R. Intraoperative assessment of parathyroid gland pathology (A common view from the surgeon and the pathologist). Am J Clin Pathol. 1994;102:365–373
  18. Johnson SJ, Sheffield EA, McNicol AM. Best practice no 183 (Examination of parathyroid gland specimens). J Clin Pathol. 2005;58:338–342
  19. Chen H, Mack E, Starling JR. Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands. Ann Surg. 2003;238:332–337
  20. Nichol PF, Mack E, Bianco J, et al. Radioguided parathyroidectomy in patients with secondary and tertiary hyperparathyroidism. Surgery. 2003;134:713–717
  21. Ogi S, Fukumitsu N, Uchiyama M, et al. The usefulness of radio-guided surgery in secondary hyperparathyroidism. Ann Nucl Med. 2004;18:69–71
  22. McGreal G, Winter DC, Sookhai S, et al. Minimally invasive, radioguided surgery for primary hyperparathyroidism. Ann Surg Oncol. 2001;8:856–860
  23. Mariani G, Gulec SA, Rubello D, et al. Preoperative localization and radioguided parathyroid surgery. J Nucl Med. 2003;44:1443–1458
  24. Jaskowiak NT, Sugg SL, Helke J, et al. Pitfalls of intraoperative quick parathyroid hormone monitoring and gamma probe localization in surgery for primary hyperparathyroidism. Arch Surg. 2002;137:659–668
  25. Burkey SH, Van Heerden JA, Farley DR, et al. Will directed parathyroidectomy utilizing the gamma probe or intraoperative parathyroid hormone assay replace bilateral cervical exploration as the preferred operation for primary hyperparathyroidism?. World J Surg. 2002;26:914–920
  26. Navarra G, Feggi L, Ascanelli S, et al. Role of radio-guided surgery in recurrent secondary hyperparathyroidism. Nephron. 2001;88:36–38
  27. Takeyama H, Shioya H, Mori Y, et al. Usefulness of radio-guided surgery using technetium-99m methoxyisobutylisonitrile for primary and secondary hyperparathyroidism. World J Surg. 2004;28:576–582
  28. Hindie E, Urena P, Jeanguillaume C, et al. Preoperative imaging of parathyroid glands with technetium-99m-labelled sestamibi and iodine-123 subtraction scanning in secondary hyperparathyroidism. Lancet. 1999;353:2200–2204
  29. Neumann DR, Esselstyn CB, Madera A, et al. Parathyroid detection in secondary hyperparathyroidism with 123I/99mTc-sestamibi subtraction single photon emission computed tomography. J Clin Endocrinol Metab. 1998;83:3867–3871
  30. Chen H, Mack E, Starling JR. Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands. Ann Surg. 2003;238:332–337
  31. Fernandez KL, Turer P, Spiegler EJ, et al. The use of sestamibi imaging in parathyroid hyperplasia. Clin Nucl Med. 2002;27:865–867
  32. Dackiw AP, Sussman JJ, Fritsche HA, et al. Relative contributions of technetium Tc 99m sestamibi scintigraphy, intraoperative gamma probe detection, and the rapid parathyroid hormone assay to the surgical management of hyperparathyroidism. Arch Surg. 2000;135:550–555
  33. Pattou FN, Pellissier LC, Noel C, et al. Supernumerary parathyroid glands: frequency and surgical significance in treatment of renal hyperparathyroidism. World J Surg. 2000;24:1330–1334

PII: S0002-9610(08)00165-7

doi: 10.1016/j.amjsurg.2007.05.059

The American Journal of Surgery
Volume 196, Issue 1 , Pages 13-18 , July 2008