The American Journal of Surgery
Volume 196, Issue 5 , Pages 663-669 , November 2008

Alteration of α-spectrin ubiquitination after hemorrhagic shock

  • Kimberly Caprio, M.D.

      Affiliations

    • Veterans Administration New Jersey Health Care System, East Orange, NJ, USA
    • Department of Surgery, New Jersey Medical School, Newark, NJ, USA
    • ,
  • Michael R. Condon, Ph.D.

      Affiliations

    • Veterans Administration New Jersey Health Care System, East Orange, NJ, USA
    • Department of Surgery, New Jersey Medical School, Newark, NJ, USA
    • ,
  • Edward A. Deitch, M.D.

      Affiliations

    • Department of Surgery, New Jersey Medical School, Newark, NJ, USA
    • ,
  • Da-Zhang Xu, M.D.

      Affiliations

    • Department of Surgery, New Jersey Medical School, Newark, NJ, USA
    • ,
  • Eleonora Feketova, M.D.

      Affiliations

    • Veterans Administration New Jersey Health Care System, East Orange, NJ, USA
    • Department of Surgery, New Jersey Medical School, Newark, NJ, USA
    • ,
  • George W. Machiedo, M.D.

      Affiliations

    • Veterans Administration New Jersey Health Care System, East Orange, NJ, USA
    • Department of Surgery, New Jersey Medical School, Newark, NJ, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-973-676-1000, ext. 1844; fax: +1-973-395-7193

Received 21 May 2008 ,Revised 21 July 2008

References 

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  4. van Bommel J, de Korte D, Lind A, et al. The effect of the transfusion of stored RBCs on intestinal microvascular oxygenation in the rat. Transfusion. 2001;41:1515–1523
  5. Zaets SB, Berezina TL, Morgan C, et al. Effect of trauma-hemorrhagic shock on red blood cell deformability and shape. Shock. 2003;19:268–273
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  12. Hsu YJ, Zimmer WE, Goodman SR. Erythrocyte spectrin's chimeric E2/E3 ubiquitin conjugating/ligating activity. Cell Mol Biol. 2005;51:187–193
  13. Liu SC, Palek J, Yi SJ, et al. Molecular basis of altered red blood cell membrane properties in Southeast Asian ovalocytosis: Role of the mutant band 3 protein in band 3 oligomerization and retention by the membrane skeleton. Blood. 1995;86:349–358
  14. Pedroni S, Lecomte MC, Gautero H, et al. Heterogeneous phosphorylation of erythrocyte spectrin beta chain in intact cells. Biochem J. 1993;294:841–846
  15. Schwartz RS, Masden JW, Rybicki AC, et al. Oxidation of spectrin and deformability defects in diabetic erythrocytes. Diabetes. 1991;40:701–708
  16. Chang TL, Kakhniashvili DG, Goodman SR. Spectrin's E2/E3 ubiquitin conjugating/ligating activity is decreased in sickle cells. Am J Hematol. 2005;79:89–96
  17. Snyder LM, Fortier FJ, Trainor J, et al. Effect of hydrogen peroxide exposure on normal human erythrocyte deformability, morphology, surface characteristics and spectrin-hemoglobin cross-linking. J Clin Invest. 1985;76:1971–1977
  18. Barbul A, Zipser Y, Nachles A, et al. Deoxygenation and increase of intracellular magnesium induce tyrosine phosphorylation of band 3 in human erythrocytes. FEBS Lett. 1999;455:87–91
  19. Manno S, Takakuwa Y, Nagao K, et al. Modulation of erythrocyte membrane mechanical function by beta-spectrin phosphorylation and dephosphorylation. J Biol Chem. 1995;270:5659–5665
  20. Chang TL, Cubillos F, Kakhniashvili DG, et al. Ankyrin is a target of spectrin's E2/E3 ubiquitin-conjugating/ligating activity. Cell Mol Biol. 2004;50:59–66
  21. Chang TL, Cubillos F, Kakhniashvili DG, et al. Band 3 is a target protein of spectrin's E2/E3 activity: Implication for sickle cell disease and normal red blood cell aging. Cell Mol Biol. 2004;50:171–177
  22. Weissman AM. Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol. 2001;2:169–178
  23. Ghatpande SS, Goodman SR. Ubiquitination of spectrin regulates the erythrocyte spectrin-protein 4.1-actin ternary complex dissociation: Implications for the sickle cell membrane skeletons. Cell Mol Biol. 2004;50:67–74
  24. Mishra R, Goodman SR. Ubiquitination of spectrin regulates the dissociation of the spectrin-adducin-F-actin ternary complex in vitro. Cell Mol Biol. 2004;50:75–80

PII: S0002-9610(08)00610-7

doi: 10.1016/j.amjsurg.2008.07.019

The American Journal of Surgery
Volume 196, Issue 5 , Pages 663-669 , November 2008

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