The American Journal of Surgery
Volume 197, Issue 2 , Pages 147-154 , February 2009

17β-estradiol mediates protection against microvascular endothelial cell hyperpermeability

Presented at the 17th annual meeting of the Society of Black Academic Surgeons, April 17–20, 2008, Cleveland, OH.

  • Binu Tharakan, Ph.D.

      Affiliations

    • Department of Surgery, College of Medicine, Texas A&M University Health Science Center, Temple, TX, United States
    • Scott and White Memorial Hospital, Temple, TX, United States
    • ,
  • Robert Corprew, M.D.

      Affiliations

    • Department of Surgery, College of Medicine, Texas A&M University Health Science Center, Temple, TX, United States
    • Scott and White Memorial Hospital, Temple, TX, United States
    • ,
  • Felicia A. Hunter, B.S.

      Affiliations

    • Department of Surgery, College of Medicine, Texas A&M University Health Science Center, Temple, TX, United States
    • Scott and White Memorial Hospital, Temple, TX, United States
    • ,
  • J. Greg Whaley, M.D.

      Affiliations

    • Department of Surgery, College of Medicine, Texas A&M University Health Science Center, Temple, TX, United States
    • Scott and White Memorial Hospital, Temple, TX, United States
    • ,
  • W. Roy Smythe, M.D.

      Affiliations

    • Department of Surgery, College of Medicine, Texas A&M University Health Science Center, Temple, TX, United States
    • Scott and White Memorial Hospital, Temple, TX, United States
    • ,
  • Ed W. Childs, M.D.

      Affiliations

    • Department of Surgery, College of Medicine, Texas A&M University Health Science Center, Temple, TX, United States
    • Scott and White Memorial Hospital, Temple, TX, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1-254-724-9087; fax: +1-254-724-7912

Received 22 May 2008 ,Revised 10 October 2008

References 

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  2. McDonald DM. Endothelial gaps: plasma leakage during inflammation. News Physiol Sci. 1998;13:104–105
  3. Childs EW, Udobi KF, Hunter FA, et al. Evidence of transcellular albumin transport after hemorrhagic shock. Shock. 2005;23:565–570
  4. Childs EW, Udobi KF, Wood JG, et al. In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. Shock. 2002;18:423–427
  5. Davidson MT, Deitch EA, Lu Q, et al. Trauma-hemorrhagic shock mesenteric lymph induced endothelial apoptosis that involves both caspase-dependent and caspase-independent mechanisms. Ann Surg. 2004;240:123–131
  6. Mauriz JL, Gonzalez P, Jorquera F, et al. Caspase inhibition does not protect against liver damage in hemorrhagic shock. Shock. 2003;19:33–37
  7. Murao Y, Hata M, Ohnishi K, et al. Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Shock. 2003;20:23–28
  8. Childs EW, Tharakan B, Hunter FA, et al. Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circul Physiol. 2007;292P:H3179–H3189
  9. Childs EW, Tharakan B, Byrge N, et al. Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circul Physiol. 2008;294:H2285–H2295
  10. Tharakan B, Holder-Haynes JG, Hunter FA, et al. Alpha lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling. Am J Surg. 2008;195:174–178
  11. Hildebrand F, Thobe BM, Hubbard WJ, et al. Effects of 17β-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage. Cytokines. 2006;36:107–114
  12. Suzuki T, Shimizu T, Yu HP, et al. Salutary effects of 17β-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily by way of estrogen receptor-alpha. Am J Physiol: Cell Physiol. 2007;292:C2103–C2111
  13. Duckles SP, Krause DN, Stirone C, et al. Estrogen and mitochondria: a new paradigm for vascular protection?. Mol Interv. 2006;6:26–35
  14. Mizushima Y, Wang P, Jarrar D, et al. Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals. Ann Surg. 2000;232:673–679
  15. Colburn P, Buonassisi V. Estrogen-binding sites in endothelial cell cultures. Science. 1978;201:817–819
  16. Kim-Schulze S, McGowan KA, Hubchak SC, et al. Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells. Circulation. 1996;94:1402–1407
  17. Venkov CD, Rankin AB, Vaughan DE. Identification of authentic estrogen receptor in cultured endothelial cells (A potential mechanism for steroid hormone regulation of endothelial function). Circulation. 1996;94:727–733
  18. Lu A, Frink M, Choudhry MA, et al. Mitochondria play an important role in 17β-estradiol attenuation of H(2)O(2)-induced rat endothelial cell apoptosis. Am J Physiol Endocrinol Metab. 2007;292:E585–E93
  19. Alvarez RJ, Gips SJ, Moldovan N, et al. 17β-estradiol inhibits apoptosis of endothelial cells. Biochem Biophys Res Commun. 1997;237:372–381
  20. Yager JD, Chen JQ. Mitochondrial estrogen receptors—new insights into specific functions. Trends Endocrinol Metab. 2007;18:89–91
  21. Li AE, Ito H, Rovira II, et al. A role for reactive oxygen species in endothelial cell Anoikis. Circul Res. 1999;85:304–310
  22. Petrosillo G, Ruggiero FM, Paradies G. Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria. FASEB J. 2003;17:2202–2208
  23. Sugawara T, Noshita N, Lewen A, et al. Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci. 2002;22:209–217
  24. Steinhusen U, Badock V, Bauer A, et al. Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem. 2000;275:16345–16353

PII: S0002-9610(08)00746-0

doi: 10.1016/j.amjsurg.2008.10.003

The American Journal of Surgery
Volume 197, Issue 2 , Pages 147-154 , February 2009

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