The American Journal of Surgery
Volume 197, Issue 3 , Pages 313-319 , March 2009

Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway

  • Scott N. Pinchot, M.D.

      Affiliations

    • Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI, USA
    • ,
  • Joel T. Adler, B.A.

      Affiliations

    • Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI, USA
    • ,
  • Yinggang Luo, Ph.D.

      Affiliations

    • Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, USA
    • ,
  • Jianhua Ju, Ph.D.

      Affiliations

    • Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, USA
    • ,
  • Wenli Li, Ph.D.

      Affiliations

    • Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, USA
    • ,
  • Ben Shen, Ph.D.

      Affiliations

    • Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI, USA
    • University of Wisconsin National Cooperative, Drug Discovery Group, Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA
    • ,
  • Muthusamy Kunnimalaiyaan, Ph.D.

      Affiliations

    • Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI, USA
    • ,
  • Herbert Chen, M.D., F.A.C.S

      Affiliations

    • Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, WI, USA
    • Corresponding Author InformationCorresponding author. Tel.: +01-608-263-1387; fax: +01-608-263-7652

Received 1 October 2008 ,Revised 31 October 2008

References 

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  14. Lee JH, Lee JS, Kim SE, et al. Tautomycetin inhibits growth of colorectal cancer cells through p21Cip/Waf induction via the extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2006;5:3222–3231
  15. Van Gompel JJ, Kunnimalaiyaan M, Holen K, et al. ZM336372, a ref-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Mol Cancer Ther. 2005;4:910–917
  16. Woods D, Parry D, Cherwinski H, et al. Ref-induced proliferation of cell cycle arrest is determined by the level of ref activity with arrest mediated by p21Cip1. Mol Cell Biol. 1997;17:5598–5611
  17. Park KS, Lee NG, Lee KH, et al. The ERK pathway involved positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc. Am J Physiol Gastrointest Liver Physiol. 2003;285:G1181–G1188
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  19. Kerkhoff E, Rapp UR. Cell cycle targets of ras/ref signaling. Oncogene. 1993;17:1457–1462
  20. Chen H, Kunnimalaiyaan M, Van Gompel JJ. Medullary thyroid cancer: the functions of ref-1 and human achaete-scute homologue-1. Thyroid. 2006;15:511–521
  21. Chen H, Hardacre JM, Uzar A, et al. Isolated liver metastases from neuroendocrine tumors: does resection prolong survival?. J Am Coll Surg. 1998;187:88–92
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  27. Li W, Ju J, Osada H, et al. Utilization of the methoxy malonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus. J Bacteriol. 2006;188:4148–4152

PII: S0002-9610(08)00778-2

doi: 10.1016/j.amjsurg.2008.10.007

The American Journal of Surgery
Volume 197, Issue 3 , Pages 313-319 , March 2009

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