The American Journal of Surgery
Volume 198, Issue 2 , Pages 231-236 , August 2009

Can intravenous lidocaine decrease postsurgical ileus and shorten hospital stay in elective bowel surgery? A pilot study and literature review

Received 17 February 2008 ,Revised 20 October 2008

References 

  1. Livingston EH, Passaro EP. Postoperative ileus. Digest Dis Sci. 1990;35:121–132
  2. Holtek K, Kehlet H. Postoperative ileus: progress towards effective management. Drugs. 2002;62:2603–2615
  3. Carli F, Trudel JL, Belliveau P. The effect of intraoperative thoracic epidural anesthesia and postoperative analgesia on bowel function after colorectal surgery. Dis Colon Rectum. 2001;44:1083–1089
  4. Baig MK, Wexner SD. Postoperative ileus: a review. Dis Colon Rectum. 2004;47:516–526
  5. Steinbrook RA. Epidural anesthesia and gastrointestinal motility. Anesth Analg. 1998;86:837–844
  6. Taguchi A, Sharma N, Saleem RM, et al. Selective postoperative inhibition of gastrointestinal opioid receptors. N Engl J Med. 2001;345:935–940
  7. Petros JG, Realica R, Ahmad S, et al. Patient-controlled analgesia and prolonged ileus after uncomplicated colectomy. Am J Surg. 1995;170:371–374
  8. Souter AJ, Fredman B, White PF. Controversies in the perioperative use of nonsteroidal antiinflammatory drugs. Anesth Analg. 1994;79:1178–1190
  9. Ferraz AAB, Cowles VE, Condon RE, et al. Opioid and nonopioid analgesic drug effects on colon contractions in monkeys. Dig Dis Sci. 1995;40:1417–1419
  10. Parker RK, Holtmann B, Smith I, et al. Use of ketorolac after lower abdominal surgery. Anesthesiology. 1994;80:6–12
  11. Cepeda MS, Delgado M, Ponce M, et al. Equivalent outcomes during postoperative patient-controlled intravenous analgesia with lidocaine plus morphine versus morphine alone. Anesth Analg. 1996;83:102–106
  12. Rimback G, Cassuto J, Wallin G, et al. Inhibition of peritonitis by amide local anesthetics. Anesthesiology. 1988;69:881–886
  13. Griffin MJ, Brennan L, McShane AJ. Preoperative education and outcome of patient controlled analgesia. Can J Anesth. 1998;45:943–948
  14. Stoelting RK. Pharmacology and physiology in anesthetic. In:  Stoelting RK editors. Practice. 3rd ed.. Philadelphia, PA: Lippincott; 1999;p. 167–170
  15. Omoigui S. Anesthesia Drugs Handbook. In: 3rd ed.. Malden, MA: Blackwell Science; 1999;p. 236–245
  16. Williams D, Stark R. Intravenous lidocaine infusion for the treatment of chronic daily headache with substantial medication overuse. Cephalalgia. 2003;23:963–971
  17. Koppert W, Weigand M, Neumann F, et al. Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth Anal. 2004;98:1050–1055
  18. Rimback G, Cassuto J, Tollesson PO. Treatment of postoperative paralytic ileus by intravenous lidocaine infusion. Anesth Analg. 1990;70:414–419
  19. Groudine SB, Fisher HAG, Kaufman RP, et al. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesth Analg. 1998;86:235–239
  20. Cassuto J, Wallin G, Hogstrom S, et al. Inhibition of postoperative pain by continuous low-dose intravenous infusion of lidocaine. Anesth Analg. 1985;64:971–974
  21. Kehlet H, Holte K. Review of postoperative ileus. Am J Surg. 2001;182:3S–10S
  22. Feinstein MB, Paimre M. Pharmacological action of local anesthetics on excitation-contraction coupling in striated and smooth muscle. Fed Proc. 1969;28:1643–1648
  23. Wood JD, Harris BR. Phase relationships of the intestinal muscularis: effects of atropine and xylocaine. J Appl Physiol. 1972;32:734–737
  24. Tansy MF, Ganse G. Regional variations in responses of rat GI tract to local anesthetics. J Pharmacol Sci. 1972;61:1141–1143
  25. Wood JD. Excitation of intestinal muscle by atropine, tetrodoxin and xylocaine. Am J Physiol. 1972;222:118–125
  26. Wood JD, Marsh DR. Effects of atropine, tetrodoxin and lidocaine on rebound excitation of guinea-pig small intestine. J Pharmacol Ther. 1973;184:590–598
  27. Bortoff A, Muller R. Stimulation of intestinal smooth muscle by atropine, procaine and tetrodoxin. Am J Physiol. 1975;229:1609–1613
  28. Nadrowski L. Paralytic ileus: recent advances in pathophysiology and treatment. Curr Surg. 1983;40:260–273
  29. Furness JB, Costa M. Adynamic ileus: its pathogenesis and treatment. Med Biol. 1974;52:82–89
  30. Wallin G, Cassuto J, Hogstrom S, et al. Effects of lidocaine infusion on the sympathetic response to abdominal surgery. Anesth Analg. 1987;66:1008–1013
  31. Delaney CP. Clinical perspective on postoperative ileus and the effect of opiates. Neurogastroenterol Motil. 2004;16:61–66

PII: S0002-9610(08)00892-1

doi: 10.1016/j.amjsurg.2008.10.015

The American Journal of Surgery
Volume 198, Issue 2 , Pages 231-236 , August 2009

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