The American Journal of Surgery
Volume 198, Issue 2 , Pages 193-198 , August 2009

Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitis

  • Michael Sand, M.D.

      Affiliations

    • Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr. 26, 44791, Bochum, Germany
    • ,
  • Falk G. Bechara, M.D.

      Affiliations

    • Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, Germany
    • ,
  • Tim Holland-Letz, M.S.

      Affiliations

    • Department of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Bochum, Germany
    • ,
  • Daniel Sand, B.S.

      Affiliations

    • Department of Physiological Science, University of California Los Angeles (UCLA), Los Angeles, CA, USA
    • Corresponding Author InformationCorresponding author: Tel.: +01149-234-517-0; fax: +01149-234-517-2503
    • ,
  • Gudrun Mehnert, M.D.

      Affiliations

    • Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr. 26, 44791, Bochum, Germany
    • ,
  • Benno Mann, M.D.

      Affiliations

    • Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr. 26, 44791, Bochum, Germany

Received 30 July 2008 ,Revised 29 August 2008

References 

  1. Schwarz A, Bolke E, Peiper M, et al. Inflammatory peritoneal reaction after perforated appendicitis: continuous peritoneal lavage versus non lavage. Eur J Med Res. 2007;12:200–205
  2. Estrada JJ, Petrosyan M, Barnhart J, et al. Hyperbilirubinemia in appendicitis: a new predictor of perforation. J Gastrointest Surg. 2007;11:714–718
  3. Bixby SD, Lucey BC, Soto JA, et al. Perforated versus nonperforated acute appendicitis: accuracy of multidetector CT detection. Radiology. 2006;241:780–786
  4. Chand N, Sanyal AJ. Sepsis induced cholestasis. J Hepatol. 2007;45:230–241
  5. Geier A, Fickert P, Trauner M. Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis. Nat Clin Pract Gastroenterol Hepatol. 2006;3:574–585
  6. Baron EJ, Bennion RS, Thompson JE, et al. A microbial comparison between acute and complicated appendicitis. Clin Infect Dis. 1992;14:227–231
  7. Rink RD, Kaelin CR, Giammara B, et al. Effects of live Escherichia coli and Bacteroides fragilis on metabolism and hepatic pO2. Circ Shock. 1981;8:601–611
  8. Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology. 1996;111:193–198
  9. Utili R, Abernathy CO, Zimmerman HJ. Cholestatic effects of Escherichia coli endotoxin on the isolated perfused rat liver. Gastroenterology. 1976;70:248–253
  10. Shander A. Anemia in the critically ill. Crit Care Clin. 2004;20:159–178
  11. Agrez MV, House AK, Quinlan MF. Jaundice may herald an appendiceal abscess. Aust N Z J Surg. 1986;56:511–513
  12. Dawes T, Burrows C. Abdominal pain and jaundice: appendiceal perforation an important differential. Emerg Med. 2007;19:276–278
  13. Seller RA. Jaundice in acute appendicitis. Lancet. 1969;1:838
  14. Ogilvie TA. Acholuric jaundice and appendicitis. Br J Surg. 1951;38:529–530
  15. Meyer G, Landi JP, Pitchumont CS. Acute appendicitis presenting as cholestatic jaundice. N Y State J Med. 1984;84:131–132
  16. Miller DF, Irvine RW. Jaundice in acute appendicitis. Lancet. 1969;1:321–323

 All authors hereby disclose any commercial associations that might pose or create a conflict of interest with information presented in this article.

PII: S0002-9610(09)00010-5

doi: 10.1016/j.amjsurg.2008.08.026

The American Journal of Surgery
Volume 198, Issue 2 , Pages 193-198 , August 2009

Article Tools

* Image Usage & Resolution