Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats
Abstract
Background
The effect of glutamine-enriched early enteral nutrition (Gln-EEN) on intestinal mucosal barrier injury after liver transplantation (LT) remains uncertain.
Methods
The Wistar-to-Wistar rat LT model was used to explore the protective effect of Gln-EEN. Morphologic changes of intestinal mucosa, levels of intestinal malondialdehyde and secretory immunoglobulin (sIgA), plasma endotoxin, D-lactic acid, serum tumor necrosis factor-α (TNF-α), rates of bacterial translocation, and expression of intestinal nuclear factor-κB, TNF-α, and intercellular adhesion molecule-1 were determined.
Results
After LT, intestinal mucosa was damaged seriously. At 12, 24, and 48 hours posttransplantation, levels of intestinal sIgA were decreased; levels of malondialdehyde, endotoxin, D-lactic acid, and TNF-α, the ratio of bacterial translocation, and the expression of intestinal nuclear factor-κB, TNF-α, and intercellular adhesion molecule-1 all were increased. However, changes in earlier-mentioned parameters in recipients treated with Gln-EEN were attenuated remarkably at 24 to 48 hours.
Conclusions
Our data show that Gln-EEN is a potent protectant against intestinal mucosal barrier injury after LT.
Keywords: Glutamine, Enteral nutrition, Liver transplantation, Bacterial translocation, Mucosal barrier
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The authors have no financial conflicts of interest.
Y.L. and Y.C. contributed equally to this work.
PII: S0002-9610(09)00108-1
doi:10.1016/j.amjsurg.2008.11.039
© 2010 Elsevier Inc. All rights reserved.
