The American Journal of Surgery
Volume 199, Issue 1 , Pages 35-42 , January 2010

Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats

  • Yang Li, Ph.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Yong Chen, Ph.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • Department of Hepatobiliary Surgery, The First Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Juan Zhang, M.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Ji-Fang Zhu, Ph.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Zuo-Jin Liu, Ph.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Shao-Yong Liang, Ph.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Ke Sun, M.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Wang-Yang Liao, M.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • ,
  • Jian-Ping Gong, Ph.D.

      Affiliations

    • Chongqing Key Laboratory of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, 400016, Chongqing, P.R China
    • Corresponding Author InformationCorresponding author: Tel.: +86-23-63693532; fax: +86-23-63829191

Received 11 September 2008 ,Revised 28 November 2008

References 

  1. Mueller AR, Platz KP, Kremer B. Early postoperative complications following liver transplantation. Best Pract Res Clin Gastroenterol. 2004;18:881–900
  2. Echaniz A, Pita S, Otero A, et al. 1. Incidence, risk factors and influence on survival of infectious complications in liver transplantation. Enferm Infect Microbiol Clin. 2003;21:224–231
  3. Bedirli A, Sakrak O, Soyuer I, et al. Portosystemic shunt prevents apoptosis in rat intestinal mucosa caused by total hepatic ischemia. Eur Surg Res. 2004;36:293–299
  4. Rayes N, Seehofer D, Hansen S, et al. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation. 2002;74:123–127
  5. Nakao M, Ogura Y, Satake S, et al. Usefulness of soluble dietary fiber for the treatment of diarrhea during enteral nutrition in elderly patients. Nutrition. 2002;18:35–39
  6. Olah A, Belagyi T, Issekutz A, et al. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg. 2002;89:1103–1107
  7. Heys SD, Ashkanani F. Glutamine. Br J Surg. 1999;86:289–290
  8. Li JY, Lu Y, Hu S, et al. Prevention effect of glutamine on intestinal barrier dysfunction induced by severe trauma. World J Gastroenterol. 2002;8:168–171
  9. Wilmore DW. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J Nutr. 2001;131(Suppl):2543S–2549S
  10. Petrov MS, Kukosh MV, Emelyanov NV. A randomized controlled trial of enteral versus parenteral feeding in patients with predicted severe acute pancreatitis shows a significant reduction in mortality and in infected pancreatic complications with total enteral nutrition. Digest Surg. 2006;23:336–345
  11. Bastian L, Weimann A. Immunonutrition in patients after multiple trauma. Br J Nutr. 2002;87(Suppl):S133–S134
  12. Szalay L, Umar F, Khadem A, et al. Increased plasma D-lactate is associated with the severity of hemorrhagic/traumatic shock in rats. Shock. 2003;20:245–250
  13. Zuo GQ, Gong JP, Liu CA, et al. Synthesis of Toll-like receptor 4 in Kupffer cells and its role in alcohol-induced liver disease. Chin Med J. 2003;116:297–300
  14. Chen Y, Liu Z, Liang S, et al. Role of Kupffer cells in the induction of tolerance of orthotopic liver transplantation in rats. Liver Transpl. 2008;14:823–836
  15. Chang JX, Chen S, Ma LP, et al. Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock. World J Gastroenterol. 2005;11:5485–5491
  16. Ammori BJ. Role of the gut in the course of severe acute pancreatitis. Pancreas. 2003;26:122–129
  17. Kraehenbuhl JP, Pringault E, Neutra MR. Review article: intestinal epithelia and barrier functions. Aliment Pharmacol Ther. 1997;11(Suppl 3):3–9
  18. Harari Y, Weisbrodt NW, Moody FG. Ileal mucosal response to bacterial toxin challenge. J Trauma. 2000;49:306–313
  19. Nagler-Anderson C. Man the barrier! Strategic defences in the intestinal mucosa. Nat Rev Immunol. 2001;1:59–67
  20. Pierro A, Eaton S. Intestinal ischemia reperfusion injury and multisystem organ failure. Semin Pediatr Surg. 2004;13:11–17
  21. Agarwal S, Deschner J, Long P, et al. Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum. 2004;50:3541–3548
  22. Sun D, Chen D, Du B, et al. Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells. J Surg Res. 2005;129:114–121
  23. Edelman DA, Jiang Y, Tyburski JG, et al. Cytokine production in lipopolysaccharide-exposed rat lung pericytes. J Trauma. 2007;62:89–93
  24. Sumagin R, Sarelius IH. TNF-alpha activation of arterioles and venules alters distribution and levels of ICAM-1 and affects leukocyte-endothelial cell interactions. Am J Physiol Heart Circ Physiol. 2006;291:H2116–H2125
  25. Hokari R, Tsuzuki Y, Miura S. The role of TNF-alpha in ischemic disease of mesenteric venous systems. J Gastroenterol. 2004;39:1120–1122
  26. Boivin MA, Ye D, Kennedy JC, et al. Mechanism of glucocorticoid regulation of the intestinal tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2007;292:G590–G598

 The authors have no financial conflicts of interest.

 Y.L. and Y.C. contributed equally to this work.

PII: S0002-9610(09)00108-1

doi: 10.1016/j.amjsurg.2008.11.039

The American Journal of Surgery
Volume 199, Issue 1 , Pages 35-42 , January 2010

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