Factors associated with improved outcome after surgery in metastatic breast cancer patients

McGuire, Kandace P.; Eisen, Sarah; Rodriguez, Amilcar; Meade, Tammi; Cox, Charles E.; Khakpour, Nazanin

doi:10.1016/j.amjsurg.2009.06.011

« Previous Next »The American Journal of Surgery
Volume 198, Issue 4 , Pages 511-515, October 2009

Factors associated with improved outcome after surgery in metastatic breast cancer patients

Moffitt Cancer Center, 12901 Magnolia Dr., Tampa, FL 33612, USA

Received 31 March 2009; received in revised form 14 June 2009

Abstract

Background

Recent studies suggest local surgical therapy improves survival in metastatic breast cancer (MBC). We evaluate the difference in outcome in patients with MBC after mastectomy versus breast conservation (BCT) and factors that influence outcome.

Methods

In a retrospective review of our prospective database, we identified patients who presented with MBC (1990 to 2007). Patient surgery type and clinicopathologic factors were reviewed. We compared OS between pts dependent on surgery and clinicopathologic factors.

Results

Of the 566 patients with MBC, 154 (27%) underwent removal of the primary tumor. Surgery was associated with an improved OS (33%) versus no surgery (20%) (P = 0.0015). Of those undergoing local therapy; mastectomy was associated with a 37% OS vs BCT with a 20% OS (P = 0.04).

Conclusions

Our study confirms that removal of the primary tumor in MBC is associated with improved overall survival. It appears that mastectomy is associated with a significantly improved overall survival.

Keywords: Surgery, Stage IV, Metastatic, Breast cancer