The American Journal of Surgery
Volume 200, Issue 1 , Pages 41-46 , July 2010

Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Ḧurthle-cell neoplasms of the thyroid

  • Insoo Suh, M.D.

      Affiliations

    • Department of Surgery, University of California, San Francisco, 513 Parnassus Ave., Box 0470, San Francisco, CA 94143-0470, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-415-476-1239; fax: +1-415-502-1259
    • ,
  • Menno R. Vriens, M.D., Ph.D.

      Affiliations

    • Department of Surgery, University of California, San Francisco, 513 Parnassus Ave., Box 0470, San Francisco, CA 94143-0470, USA
    • ,
  • Marlon A. Guerrero, M.D.

      Affiliations

    • Department of Surgery, University of California, San Francisco, 513 Parnassus Ave., Box 0470, San Francisco, CA 94143-0470, USA
    • ,
  • Ann Griffin, Ph.D.

      Affiliations

    • Cancer Center Registry, University of California, San Francisco, CA, USA
    • ,
  • Wen T. Shen, M.D.

      Affiliations

    • Department of Surgery, University of California, San Francisco, 513 Parnassus Ave., Box 0470, San Francisco, CA 94143-0470, USA
    • ,
  • Quan-Yang Duh, M.D.

      Affiliations

    • Department of Surgery, University of California, San Francisco, 513 Parnassus Ave., Box 0470, San Francisco, CA 94143-0470, USA
    • ,
  • Orlo H. Clark, M.D.

      Affiliations

    • Department of Surgery, University of California, San Francisco, 513 Parnassus Ave., Box 0470, San Francisco, CA 94143-0470, USA
    • ,
  • Electron Kebebew, M.D.

      Affiliations

    • Department of Surgery, University of California, San Francisco, 513 Parnassus Ave., Box 0470, San Francisco, CA 94143-0470, USA

Received 15 June 2009 ,Revised 17 August 2009

References 

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  2. Castro MR, Gharib H. Thyroid fine-needle aspiration biopsy: progress, practice, and pitfalls. Endocr Pract. 2003;9:128–136
  3. Ravetto C, Colombo L, Dottorini ME. Usefulness of fine-needle aspiration in the diagnosis of thyroid carcinoma: a retrospective study in 37,895 patients. Cancer. 2000;90:357–363
  4. Renshaw AA. Accuracy of thyroid fine-needle aspiration using receiver operator characteristic curves. Am J Clin Pathol. 2001;116:477–482
  5. Eustatia-Rutten CF, Smit JW, Romijn JA, et al. Diagnostic value of serum thyroglobulin measurements in the follow-up of differentiated thyroid carcinoma, a structured meta-analysis. Clin Endocrinol (Oxf). 2004;61:61–74
  6. Giovanella L. Highly sensitive thyroglobulin measurements in differentiated thyroid carcinoma management. Clin Chem Lab Med. 2008;46:1067–1073
  7. Gupta M, Chia SY. Circulating thyroid cancer markers. Curr Opin Endocrinol Diabetes Obes. 2007;14:383–388
  8. Kloos RT, Mazzaferri EL. A single recombinant human thyrotropin-stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab. 2005;90:5047–5057
  9. Leboulleux S, Rubino C, Baudin E, et al. Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis. J Clin Endocrinol Metab. 2005;90:5723–5729
  10. Whitley RJ, Ain KB. Thyroglobulin: a specific serum marker for the management of thyroid carcinoma. Clin Lab Med. 2004;24:29–47
  11. Christensen SB, Bondeson L, Ericsson UB, et al. Prediction of malignancy in the solitary thyroid nodule by physical examination, thyroid scan, fine-needle biopsy and serum thyroglobulin (A prospective study of 100 surgically treated patients). Acta Chir Scand. 1984;150:433–439
  12. Besic N, Sesek M, Peric B, et al. Predictive factors of carcinoma in 327 patients with follicular neoplasm of the thyroid. Med Sci Monit. 2008;14:CR459–CR467
  13. Hrafnkelsson J, Tulinius H, Kjeld M, et al. Serum thyroglobulin as a risk factor for thyroid carcinoma. Acta Oncol. 2000;39:973–977
  14. Panza N, Lombardi G, De Rosa M, et al. High serum thyroglobulin levels (Diagnostic indicators in patients with metastases from unknown primary sites). Cancer. 1987;60:2233–2236
  15. Lin JD. Thyroglobulin and human thyroid cancer. Clin Chim Acta. 2008;388:15–21
  16. Sharma AK, Sarda AK, Chattopadhyay TK, et al. The role of estimation of the ratio of preoperative serum thyroglobulin to the thyroid mass in predicting the behaviour of well differentiated thyroid cancers. J Postgrad Med. 1996;42:39–42
  17. Schlumberger M, Hitzel A, Toubert ME, et al. Comparison of seven serum thyroglobulin assays in the follow-up of papillary and follicular thyroid cancer patients. J Clin Endocrinol Metab. 2007;92:2487–2495
  18. Mazzaferri EL, Kloos RT. Using recombinant human TSH in the management of well-differentiated thyroid cancer: current strategies and future directions. Thyroid. 2000;10:767–778
  19. Maddox PR, Wheeler MH. Approach to thyroid nodules. In:  Clark OH,  Duh QY,  Kebebew E editor. Textbook of Endocrine Surgery. 2nd ed.. Philadelphia: Elsevier Saunders; 2005;p. 85–92
  20. Okamoto T, Kanbe M, Iihara M, et al. Measuring serum thyroglobulin in patients with follicular thyroid nodule: its diagnostic implications. Endocr J. 1997;44:187–193
  21. Baloch ZW, Hendreen S, Gupta PK, et al. Interinstitutional review of thyroid fine-needle aspirations: impact on clinical management of thyroid nodules. Diagn Cytopathol. 2001;25:231–234
  22. Tan YY, Kebebew E, Reiff E, et al. Does routine consultation of thyroid fine-needle aspiration cytology change surgical management?. J Am Coll Surg. 2007;205:8–12
  23. Lever EG, Refetoff S, Scherberg NH, et al. The influence of percutaneous fine needle aspiration on serum thyroglobulin. J Clin Endocrinol Metab. 1983;56:26–29

PII: S0002-9610(09)00710-7

doi: 10.1016/j.amjsurg.2009.08.030

The American Journal of Surgery
Volume 200, Issue 1 , Pages 41-46 , July 2010

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