The American Journal of Surgery
Volume 200, Issue 2 , Pages 276-282 , August 2010

The omentum is a site of stromal cell–derived factor 1α production and reservoir for CXC chemokine receptor 4–positive cell recruitment

  • Naveed U. Saqib, M.D.

      Affiliations

    • Department of Surgery, University of New Mexico HSC, MSC 105610, Albuquerque, NM 87131, USA
    • ,
  • Paul G. McGuire, Ph.D.

      Affiliations

    • Department of Cell Biology and Physiology, University of New Mexico HSC, Albuquerque, NM, USA
    • ,
  • Thomas R. Howdieshell, M.D.

      Affiliations

    • Department of Surgery, University of New Mexico HSC, MSC 105610, Albuquerque, NM 87131, USA
    • Corresponding Author InformationCorresponding author: Tel.: +1-505-272-6441; fax: +1-505-272-0432

Received 25 April 2009 ,Revised 31 August 2009

References 

  1. Pinho MB, Hurtado SP, El-Cheikh MC, et al. Myelopoiesis in the omentum of normal mice and during abdominal inflammatory processes. Cell Tissue Res. 2002;308:87–96
  2. Dux K. Proliferative activity of macrophage in the greater omentum of the mouse in relation to the early postnatal development of the vascular structure. J Leukol Biol. 1986;40:445–458
  3. Tsilibary EC, Wissig SL. Light and electron microscopic observations of the lymphatic drainage units of the peritoneal cavity of rodents. Am J Anat. 1987;180:195–207
  4. Wassilev W, Wedel T, Michailova K, et al. A scanning electron microscopy study of peritoneal stomata in different peritoneal regions. Anat Anz. 1998;180:137–143
  5. Cranshaw ML, Leak LV. Milky spots of the omentum: a source of peritoneal cells in the normal and stimulated animal. Arch Histol Cytol. 1990;53:165–177
  6. Lenzi HL, Oliveira DN, Pelajo-Machado M, et al. Coelem-associated lymphomyeloid tissue (milky spots): site of lymphoid and myelomonocytic cell generation. Braz J Med Biol Res. 1996;29:19–24
  7. Beelen RHJ, Fluitsma DM, Heofsmit ED. Cellular composition of omentum milky spots and the ultrastructure of milky spot macrophages and reticulum cells. J Reticuloendothel Soc. 1980;28:585–599
  8. Mandache E, Moldoveanu E, Savi G. The involvement of omentum and its milky spots in the dynamics of peritoneal macrophages. J Morphol Embryol. 1985;31:137–142
  9. Mutsaers SE. Mesothelial cells: their structure, function, and role in serosal repair. Respirology. 2002;7:171–191
  10. Shao ZQ, Kawasuji M, Takaji K, et al. Therapeutic angiogenesis with autologous hepatic tissue implantation and omental wrapping. Circ J. 2008;72:1894–1899
  11. Luijendijk RW, Lange DCD, Wauters CCAP, et al. Foreign material in postoperative adhesions. Ann Surg. 1996;223:242–248
  12. Litbarg NO, Gudehithlu KP, Sethupathi P, et al. Activated omentum becomes rich in factors that promote healing and tissue repair. Cell Tissue Res. 2007;331:487–497
  13. Chan TM, Yung S. Mesothelial cells. Perit Dial Int. 2007;27:S110–S115
  14. Singh AK, Patel J, Litbarg NO, et al. Stromal cells cultured from omentum express pluripotent markers, produce high amounts of VEGF, and engraft to injured sites. Cell Tissue Res. 2008;332:81–88
  15. Kim CH, Broxmeyer HE. Chemokines: signal lamps for trafficking of T and B cells for development and effector function. J Leukoc Biol. 1999;65:6–15
  16. Howdieshell TR, Riegner C, Gupta V, et al. Normoxic wound fluid contains high levels of vascular endothelial growth factor. Ann Surg. 1998;228:707–715
  17. Howdieshell TR, Webb WL, Sathanarayana , et al. Inhibition of inducible nitric oxide synthase results in reductions in wound vascular endothelial growth factor expression, granulation tissue formation, and local perfusion. Surgery. 2003;133:528–537
  18. Howdieshell TR, Callaway D, Webb WL, et al. Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation. J Surg Res. 2001;96:173–182
  19. Shirozu M, Nakano T, Inazawa J, et al. Structure and chromosomal localization of the human stromal cell-derived factor-1 (SDF-1) gene. Genomics. 1995;28:495–500
  20. Juarez J, Bendall L, Bradstock K. Chemokines and their receptors as therapeutic targets: the role of the SDF-1/CXCR4 axis. Curr Pharm Des. 2004;10:1245–1259
  21. Bleul CC, Fuhlbrigge RC, Casanovas JM, et al. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor-1 (SDF-1). J Exp Med. 1996;184:1101–1109
  22. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity. 2000;12:121–127
  23. Ganju RK, Brubaker SA, Meyer J. The alpha chemokine: stromal cell-derived factor-1, binds to the transmembrane G-protein-coupled CXCR4 receptor and activates multiple signal transduction pathways. J Biol Chem. 1998;273:23169–23175
  24. Tashiro K, Tada H, Heilker R, et al. Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science. 1993;261:600–603
  25. Horuk R. Chemokine receptors. Cytokine Growth Factor Rev. 2001;12:313–315
  26. Gupta SK, Lysko PG, Pillarisetti K, et al. Chemokine receptors in human endothelial cells, functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem. 1998;272:4282–4287
  27. Roland J, Murphy BJ, Ahr B, et al. Role of the intracellular domains of CXCR4 in SDF-1 mediated signaling. Blood. 2003;101:399–406
  28. Sambrano GR, Coughlin SR. The carboxy tail of protease-activated receptor-1 is required for chemotaxis, correlation of signal termination and directional migration. J Biol Chem. 1999;274:20178–20184
  29. Godin I, Dieterlen-Lievre F, Cumano A. Emergence of multipotent hematopoietic cells in the yolk sac and para-aortic splanchnopleura in mouse embryos beginning at 8.5 days postcoitus. Proc Natl Acad Sci U S A. 1995;92:773–777
  30. Godin I, Garcia-Porerro JA, Dieterlen-Lievre F, et al. Stem cell emergence and hematopoietic activity are incompatible in mouse intra-embryonic sites. J Exp Med. 1999;190:43–52
  31. Foussat A, Balabanian K, Amara A, et al. Production of stromal cell-derived factor-1 by mesothelial cells and effects of this chemokine on peritoneal B lymphocytes. Eur J Immunol. 2001;31:350–359
  32. Murphy PM. Chemokines and the molecular basis of cancer metastasis. N Engl J Med. 2001;345:833–835
  33. Zhang QX, Magovern CJ, Mack CA, et al. Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. J Surg Res. 1997;67:147–154
  34. Grunewald M, Avraham I, Dor Y, et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell. 2006;124:175–189
  35. Herrick SE, Mutsaers SE. The potential of mesothelial cells in tissue engineering and regenerative medicine applications. Int J Artif Organs. 2007;30:527–540
  36. Goldsmith HS. The evolution of omentum transposition: from lymphedema to spinal cord, stroke, and Alzheimer's disease. Neurol Res. 2004;26:586–593
  37. Cannady JE. Some uses of undetached omentum in surgery. Am J Surg. 1948;76:502–505
  38. Jayne DG, Perry SL, Morrison E, et al. Activated mesothelial cells produce heparin-binding growth factors: implications for tumor metastases. Br J Cancer. 2000;82:1233–1238

PII: S0002-9610(09)00711-9

doi: 10.1016/j.amjsurg.2009.08.031

The American Journal of Surgery
Volume 200, Issue 2 , Pages 276-282 , August 2010

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