The American Journal of Surgery
Volume 200, Issue 2 , Pages 252-257 , August 2010

Liver transplantation is an alternative treatment of hepatocellular carcinoma beyond the Milan criteria

  • Hsiu-Lung Fan, M.D.

      Affiliations

    • Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Teng-Wei Chen, M.D.

      Affiliations

    • Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Chung-Bao Hsieh, M.D.

      Affiliations

    • Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Hsiang-Chun Jan, M.D.

      Affiliations

    • Division of General Surgery, Department of Surgery, Cardinal Tien Hospital, Hsintien Taipei Hsien, 23137 Taiwan
    • ,
  • Sheng-Chuan His, M.D.

      Affiliations

    • Division of General Surgery, Department of Surgery, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, Republic of China
    • ,
  • Chan De-Chuan

      Affiliations

    • Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Chi-Hong Chu, Ph.D.

      Affiliations

    • Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Jyh-Cherng Yu, M.D.

      Affiliations

    • Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author: Tel.: +882-2-8792-3311; fax: +332-2-8792-7372

Received 10 April 2009 ,Revised 17 June 2009

References 

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  2. El-Serag HB. Epidemiology of hepatocellular carcinoma in USA. Hepatol Res. 2007;37:S88–S94
  3. Bosch FX, Ribes J, Díaz M, et al. Primary liver cancer: worldwide incidence and trends. Gastroenterologist. 2004;127:S5–S16
  4. Morris-Stiff G, Gomez D, de Liguori Carino N, et al. Surgical management of hepatocellular carcinoma: is the jury still out?. Surg Oncol. 2009;18:298–321
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  11. Mazzaferro V, Regalio E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693–699
  12. Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. J Hepatol. 2001;33:1394–1403
  13. Taura K, Ikai I, Hatano E, et al. Influence of coexisting cirrhosis on outcomes after partial hepatic resection for hepatocellular carcinoma fulfilling the Milan criteria: an analysis of 293 patients. Surgery. 2007;142:685–694
  14. Tanaka S, Noguchi N, Ochiai T, et al. Outcomes and recurrence of initially resectable hepatocellular carcinoma meeting Milan criteria: rationale for partial hepatectomy as first strategy. J Am Coll Surg. 2007;204:1–6
  15. Yokoi H, Isaji S, Yamagiwa K, et al. The role of living-donor liver transplantation in surgical treatment for hepatocellular carcinoma. J Hepatobil Pancreat Surg. 2006;13:123–130
  16. Hanazaki K, Kajikawa S, Shimozawa N, et al. Hepatic resection for hepatocellular carcinoma in diameter of > or = 10 cm. Hepatogastroenterology. 2002;49:518–523
  17. Figueras J, Jaurrieta E, Valls C, et al. Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: outcomes based on indicated treatment strategy. J Am Coll Surg. 2000;190:580–587
  18. Calne RY. Transplantation: current developments and future directions. Front Biosci. 2007;12:3727–3733
  19. Yi NJ, Suh KS, Kim T, et al. Current role of surgery in treatment of early stage hepatocellular carcinoma: resection versus liver transplantation. Oncology. 2008;75(suppl 1):124–128
  20. Vidal-Vanaclocha F. The prometastatic microenvironment of the liver. Cancer Microenviron. 2008;1:113–129
  21. Cherqui D. Role of adjuvant treatment in liver transplantation for advanced hepatocellular carcinoma. J Hepatobiliary Pancreat Surg. 1998;5:35–40
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PII: S0002-9610(09)00790-9

doi: 10.1016/j.amjsurg.2009.07.049

The American Journal of Surgery
Volume 200, Issue 2 , Pages 252-257 , August 2010

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