The American Journal of Surgery
Volume 200, Issue 3 , Pages 352-356 , September 2010

Prevention of seroma formation after mastectomy and axillary dissection by lymph vessel ligation and dead space closure: a randomized trial

  • Yiping Gong, M.B.

      Affiliations

    • Department of Oncological Surgery, Zhongnan Hospital, Wuhan University, 169 Donghu Rd., Wuhan 430071, Hubei, China
    • Department of Breast Surgery, Hubei Cancer Hospital, 116 South Zhuodaoquan Rd., Wuhan 430079, Hubei, China
    • ,
  • Juan Xu, M.B.

      Affiliations

    • Department of Breast Surgery, Hubei Cancer Hospital, 116 South Zhuodaoquan Rd., Wuhan 430079, Hubei, China
    • ,
  • Jun Shao, M.S.

      Affiliations

    • Department of Breast Surgery, Hubei Cancer Hospital, 116 South Zhuodaoquan Rd., Wuhan 430079, Hubei, China
    • ,
  • Hongtao Cheng, M.S.

      Affiliations

    • Department of Breast Surgery, Hubei Cancer Hospital, 116 South Zhuodaoquan Rd., Wuhan 430079, Hubei, China
    • ,
  • Xinhong Wu, Ph.D.

      Affiliations

    • Department of Breast Surgery, Hubei Cancer Hospital, 116 South Zhuodaoquan Rd., Wuhan 430079, Hubei, China
    • ,
  • Demian Zhao, M.B.

      Affiliations

    • Department of Breast Surgery, Hubei Cancer Hospital, 116 South Zhuodaoquan Rd., Wuhan 430079, Hubei, China
    • ,
  • Bin Xiong, M.D.

      Affiliations

    • Department of Oncological Surgery, Zhongnan Hospital, Wuhan University, 169 Donghu Rd., Wuhan 430071, Hubei, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 27 67813152; fax: +86 27 68754067

Received 14 June 2009 ,Revised 9 September 2009

References 

  1. Tadych K, Donegan WL. Postmastectomy seromas and wound drainage. Surg Gynecol Obstet. 1987;165:483–487
  2. Aitken D, Minton J. Complications associated with mastectomy. Surg Clin North Am. 1983;63:1331–1352
  3. Chilson TR, Chan FD, Lonser RR, et al. Seroma prevention after modified radical mastectomy. Am Surg. 1992;58:750–754
  4. Stanczyk M, Grala B, Zwierowicz T, et al. Surgical resection for persistent seroma, following modified radical mastectomy. World J Surg Oncol. 2007;5:104
  5. Boostrom SY, Throckmorton AD, Boughey JC, et al. Incidence of clinically significant seroma after breast and axillary surgery. J Am Coll Surg. 2009;208:148–150
  6. Woodworth PA, McBoyle MF, Helmer , et al. Seroma formation after breast cancer surgery: incidence and predicting factors. Am Surg. 2000;66:444–450
  7. Agrawal A, Ayantunde AA, Cheung KL. Concepts of seroma formation and prevention in breast cancer surgery. Aust NZ J Surg. 2006;76:1088–1095
  8. Watt-Boolsen S, Nielsen VB, Jensen J, et al. Postmastectomy seroma (A study of the nature and origin of seroma after mastectomy). Danish Med Bull. 1989;36:487–489
  9. Bonnema J, Ligtenstein DA, Wiggers T, et al. The composition of serous fluid after axillary dissection. Eur J Surg. 1999;165:9–13
  10. Budd DC, Cochran RC, Sturtz DL, et al. Surgical morbidity after mastectomy operations. Am J Surg. 1978;135:218–220
  11. Schuijtvlot M, Sahu AK, Cawthorn SJ. A prospective audit of the use of a buttress suture to reduce seroma formation following axillary node dissection without drains. Breast. 2002;11:94–96
  12. Ruggiero R, Procaccini E, Piazza P, et al. Effectiveness of fibrin glue in conjunction with collagen patches to reduce seroma formation after axillary lymphadenectomy for breast cancer. Am J Surg. 2008;196:170–174
  13. Carless PA, Henry DA. Systematic review and meta-analysis of the use of fibrin sealant to prevent seroma formation after breast cancer surgery. Br J Surg. 2006;93:810–819
  14. Burak WE, Goodman PS, Young DC, et al. Seroma formation following axillary dissection for breast cancer: risk factors and lack of influence of bovine thrombin. J Surg Oncol. 1997;64:27–31
  15. McCaul JA, Aslaam A, Spooner RJ, et al. Aetiology of seroma formation in patients undergoing surgery for breast cancer. Breast. 2000;9:144–148
  16. Kuroi K, Shimozuma K, Taguchi T, et al. Effect of mechanical closure of dead space on seroma formation after breast surgery. Breast Cancer. 2006;13:260–265
  17. Coveney EC, O'Dwyer PJ, Geraghty JG, et al. Effect of closing dead space on seroma formation after mastectomy—a prospective randomised clinical trial. Eur J Surg Oncol. 1993;19:143–146
  18. O'Hea BJ, Ho MN, Petrek JA. External compression dressing versus standard dressing after axillary lymphadenectomy. Am J Surg. 1999;177:450–453
  19. Classe JM, Berchery D, Campion L, et al. Randomized clinical trial comparing axillary padding with closed suction drainage for the axillary wound after lymphadenectomy for breast cancer. Br J Surg. 2006;93:820–824
  20. Kuroi K, Shimozuma K, Taguchi T, et al. Pathophysiology of seroma in breast cancer. Breast Cancer. 2005;12:288–293
  21. Purkayastha J, Hazarika S, Deo SV, et al. Post-mastectomy chylous fistula: anatomical and clinical implications. Clin Anat. 2004;17:413–415
  22. Halsted WS. Developments in the skin grafting operations for cancer of the breast. JAMA. 1913;60:416–418
  23. O'Dwyer PJ, O'Higgins NJ, James AG. Effect of closing dead space on incidence of seroma after mastectomy. Surg Gynecol Obstet. 1991;172:55–56

PII: S0002-9610(10)00061-9

doi: 10.1016/j.amjsurg.2009.10.013

The American Journal of Surgery
Volume 200, Issue 3 , Pages 352-356 , September 2010

Article Tools

* Image Usage & Resolution