The American Journal of Surgery
Volume 200, Issue 3 , Pages 368-373 , September 2010

The clinical impact and outcomes of immunohistochemistry-only metastasis in breast cancer

  • Matthew Pugliese, M.D.

      Affiliations

    • Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    • ,
  • Michelle Stempel, M.P.H.

      Affiliations

    • Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    • ,
  • Sujata Patil, Ph.D.

      Affiliations

    • Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Meier Hsu, B.A.

      Affiliations

    • Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    • ,
  • Alice Ho, M.D.

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Tiffany Traina, M.D.

      Affiliations

    • Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    • ,
  • Monica Morrow, M.D.

      Affiliations

    • Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    • ,
  • Hiram Cody III, M.D.

      Affiliations

    • Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    • ,
  • Mary L. Gemignani, M.D.

      Affiliations

    • Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-646-888-5225; fax: +1-212-717-3214

Received 19 August 2009 ,Revised 6 October 2009

References 

  1. Russo J, Frederick J, Ownby HE, et al. Predictors of recurrence and survival of patients with breast cancer. Am J Clin Pathol. 1987;88:123–131
  2. NIH. Consensus conference (Treatment of early-stage breast cancer). J Am Med Assoc. 1991;265:391–395
  3. Cabanas RM. An approach for the treatment of penile carcinoma. Cancer. 1977;39:456–466
  4. Giuliano AE, Kirgan DM, Guenther JM, et al. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg. 1994;220:391–398
  5. Krag DN, Weaver DL, Alex JC, et al. Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol. 1993;2:335–339
  6. McLaughlin SA, Wright MJ, Morris KT, et al. Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements. J Clin Oncol. 2008;26:5213–5219
  7. McLaughlin SA, Wright MJ, Morris KT, et al. Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: patient perceptions and precautionary behaviors. J Clin Oncol. 2008;26:5220–5226
  8. Silverstein MJ, Lagios MD, Recht A, et al. Image-detected breast cancer: state of the art diagnosis and treatment. J Am Coll Surg. 2005;201:586–597
  9. Dowlatshahi K, Fan M, Snider HC, et al. Lymph node micrometastases from breast carcinoma: reviewing the dilemma. Cancer. 1997;80:1188–1197
  10. Greene FL American Joint Committee on Cancer, American Cancer Society, AJCC. Cancer Staging Manual. 6th ed.. New York: Springer-Verlag; 2002;
  11. Tan LK, Giri D, Hummer AJ, et al. Occult axillary node metastases in breast cancer are prognostically significant: results in 368 node-negative patients with 20-year follow-up. J Clin Oncol. 2008;26:1803–1809
  12. Cody HS, Fey J, Akhurst T, et al. Complementarity of blue dye and isotope in sentinel node localization for breast cancer: univariate and multivariate analysis of 966 procedures. Ann Surg Oncol. 2001;8:13–19
  13. Mittendorf EA, Sahin AA, Tucker SL, et al. Lymphovascular invasion and lobular histology are associated with increased incidence of isolated tumor cells in sentinel lymph nodes from early-stage breast cancer patients. Ann Surg Oncol. 2008;15:3369–3377
  14. Cox CE, Yeatman T, Salud CJ, et al. Significance of sentinel node micrometastasis. Cancer Control. 1999;6:601–605
  15. Reed J, Rosman M, Verbanac KM, et al. Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center sentinel node multicenter study. J Am Coll Surg. 2009;208:333–340
  16. de Boer M, van Deurzen CH, van Dijck JA, et al. Micrometastases or isolated tumor cells and the outcome of breast cancer. N Engl J Med. 2009;361:653–663
  17. Cote RJ, Peterson HF, Chaiwun B, et al. Role of immunohistochemical detection of lymph-node metastases in management of breast cancer (International Breast Cancer Study Group). Lancet. 1999;354:896–900
  18. Cserni G, Gregori D, Merletti F, et al. Meta-analysis of non-sentinel node metastases associated with micrometastatic sentinel nodes in breast cancer. Br J Surg. 2004;91:1245–1252
  19. van Deurzen CH, de Boer M, Monninkhof EM, et al. Non-sentinel lymph node metastases associated with isolated breast cancer cells in the sentinel node. J Natl Cancer Inst. 2008;100:1574–1580
  20. Fisher B, Jeong JH, Anderson S, et al. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med. 2002;347:567–575
  21. Tjan-Heijnen VC, Pepels MJ, de Boer M, et al. Impact of omission of completion axillary lymph node dissection (cALND) or axillary radiotherapy (Ax RT) in breast cancer patients with micrometastases (pN1mi) or isolated tumor cells (pN0[i+]) in the sentinel lymph node (SN): results from the MIRROR study. J Clin Oncol. 2009;27:CRA506
  22. Wasif N, Ye X, Giuliano AE. Survey of ASCO Members on management of sentinel node. Micrometastases in breast cancer: variation in treatment recommendations according to specialty. Ann Surg Oncol. 2009;16:2442–2449

PII: S0002-9610(10)00067-X

doi: 10.1016/j.amjsurg.2009.10.016

The American Journal of Surgery
Volume 200, Issue 3 , Pages 368-373 , September 2010

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