The American Journal of Surgery
Volume 170, Issue 2 , Pages 126-130 , August 1995

In vivo platelet deposition on polytetrafluoroethylene coated with fibrin glue containing fibroblast growth factor 1 and heparin in a canine model

  • Claire Gosselin, MD

      Affiliations

    • Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
    • ,
  • Dewei Ren, MD

      Affiliations

    • Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
    • ,
  • Joan Ellinger

      Affiliations

    • Department of Surgery Hines VA Hospital, Hines, Illinois, USA
    • ,
  • Howard P. Greisler, MD

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to Howard P. Greisler, MD, Loyola University Medical Center, Department of Surgery, 2160 South First Avenue, Maywood, Illinois 60153.
    • Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
    • Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Maywood, Illinois, USA
    • Department of Surgery Hines VA Hospital, Hines, Illinois, USA

References 

  1. Esquivel CO, Blaisdell FW. Why small caliber vascular grafts fail: a review of clinical and experimental experience and the significance of the interaction of blood at the interface. J Surg Res. 1986;41:1–15
  2. Rutherford RB, Jones DN, Bergentz SE, et al.  Factors affecting the patency of infrainguinal bypass. J Vasc Surg. 1988;8:236–246
  3. Budd JS, Brennan J, Beard JD, et al.  Infrainguinal bypass surgery: factors determining late graft patency. Br J Surg. 1990;77:1382–1387
  4. Veith FJ, Gupta SK, Ascer E, et al.  Six-year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions. J Vasc Surg. 1986;3:104–114
  5. Greisler HP. Currently available vascular prostheses. In: New Biologic and Synthetic Vascular Prostheses. Austin: RG Landes Company Austin; 1991;p. 20–32
  6. Hall JD, Rittgers SE, Schmidt SP. Effect of controlled local acetylsalicylic acid release on in vitro platelet adhesion to vascular grafts. J Biomater Appl. 1994;8:361–384
  7. Greisler HP, Cziperle DJ, Kim DU, et al.  Enhanced endothelialization of expanded polytetrafluoroethylene grafts by fibroblast growth factor type 1 pretreatment. Surgery. 1992;112:244–255
  8. Gray JL, Kang SS, Zenni GC, et al.  FGF-1 affixation stimulates ePTFE endothelialization without intimal hyperplasia. J Surg Res. 1994;57:596–612
  9. Greisler HP, McGurrin JF, Klosak JJ, et al.  The validity of canine platelet aggregometry in predicting vascular graft patency. J Cardiovasc Surg. 1990;31:712–718
  10. Reilly CF, Kindy MS, Brown KE, et al.  Heparin prevents vascular smooth muscle cell progression through the G1 phase of the cell cycle. J Biol Chem. 1989;264:6990–6995
  11. Tina Au TYP, Kenagy RD, Clowes MM, CLowes AW. Mechanisms of inhibition by heparin of vascular smooth muscle cell proliferation and migration. Haemostasis. 1993;23:177–182
  12. Kang SS, Ren D, Gosselin C, Greisler HI. Smooth muscle cell inhibition with endothelial cell stimulation by growth regulators within a fibrin glue delivery vehicle. Surg Forum. 1994;45:355–358
  13. Rubin BG, Santoro SA, Sicard GA. Platelet interactions with the vessel wall and prosthetic grafts. Ann Vasc Surg. 1993;7:200–207
  14. Johnson PC. Platelet-mediated thrombosis in microvascular surgery: new knowledge and strategies. Plast Reconstr Surg. 1990;86:359–367
  15. Esquivel CO, Björck CG, Bergentz SE, et al.  Reduced thrombogenic characteristics of expanded polytetrafluoroethylene and poluurethane arterial grafts after heparin bonding. Surgery. 1984;95:102–107
  16. Herring MB, Gunther GR, Etchberger KJ. 111Indium is an unreliable in vivo label for vascular endothelial cells. Ann Vasc Surg. 1991;5:424–428
  17. Garrett KO, Bentz ML, Macpherson T, Johnson PC. Quantitation of platelet deposition on human arteries: assessment of the disparity between results obtained with 111indium (111In)-labelling versus scanning electron microscopy. Thromb Res. 1993;71:495–503

☆ Supported by grant RO1 HL41272 from the National Institutes of Health.Dr. Gosselin is supported by a grant from the R. Samuel McLaughlin Foundation, Toronto, Canada.

☆☆ Presented at the 23rd Annual Meeting of The Society for Clinical Vascular Surgery, Fort Lauderdale, Florida, March 22–26, 1995.

PII: S0002-9610(99)80270-0

The American Journal of Surgery
Volume 170, Issue 2 , Pages 126-130 , August 1995

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