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Scientific paper| Volume 89, ISSUE 3, P583-592, March 1955

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Alterations in blood coagulation mechanism after incompatible blood transfusion

Clinical and experimental observations
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      Abstract

      • 1.
        1. The hemorrhagic diathasis following an incompatible blood transfusion reaction is associated with thrombocytopenia, prolongation of the coagulation time, prolongation of the prothrombin time, a decrease in the circulating white blood cells, the appearance of fibrinolytic activity and of a “heparinoid” anticoagulant.
      • 2.
        (2) The reaction is somewhat different in dogs inasmuch as the fibrinogen level does not decrease as markedly as in the human case, nor does fibrinolytic activity appear.
      • 3.
        3. It is suggested that the management of these cases be a complete immediate estimate of all the major blood clotting factors with a subsequent replacement of fibrinogen or the use of an antiheparin agent wherever indicated.
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      References

        • Wiener A.S.
        Blood Groups and Transfusion.
        Charles C Thomas, Springfield, Ill1943
        • Astrowe P.S.
        Hemolysis following transfusion.
        J.A.M.A. 1922; 79: 1511-1514
        • Levine E.C.
        • Segall H.N.
        Post transfusion reaction. Alterations in blood after ether anesthesia and after blood transfusion.
        Surg., Gynec. & Obst. 1922; 35: 313-319
        • Parr L.W.
        • Krischner H.
        Hemolytic transfusion fatality with donor and recipient in the same blood group.
        J.A.M.A. 1932; 98: 47
        • Abramson M.
        Hemolytic transfusion reaction with death.
        Journal Lancet. 1935; 55: 805-807
        • Seldon T.H.
        Transfusion reaction among patients under general anesthesia.
        Mississippi Valley M. J. 1949; 71: 124-126
        • Friesen S.R.
        • Nelson R.M.
        The occurrence of massive generalized wound bleeding during operation, with reference to the possible role of blood transfusions in its etiology.
        Am. Surgeon. 1951; 17: 609-622
        • Muirhead E.E.
        Incompatible blood transfusion with emphasis on acute renal failure.
        Surg., Gynec. & Obst. 1951; 92: 734-746
        • Hardaway R.M.
        • McKay D.G.
        • Williams J.H.
        Lower nephron nephrosis (ischemuric nephrosis) with special reference to hemorrhagic diathesis following incompatible blood transfusion reaction.
        Am. J. Surg. 1954; 87: 41-49
        • Lattes L.
        Whitby L.E.H. Britton C.J.C. Disorders of the Blood. The Blakiston Co, Philadelphia1946: 535
        • Lindau
        Blood Groups and Transfusion.
        Charles C Thomas, Springfield, Ill1943 (Cited by Wiener)
        • Landois
        Die Transfusion des Blutes.
        1875 (Leipzig)
        • Melnick D.
        • Burack E.
        • Cowgill G.R.
        Development of incompatibilities in dogs by repeated infusions of red blood cells.
        in: 6th ed. Proc. Soc. Exper. Biol. & Med.33. 1935: 616-621
        • Young L.E.
        • Erwin D.M.
        • Yuile C.L.
        Hemolytic reactions produced in dogs by transfusion of incompatible dog blood and plasma.
        Blood. 1949; 4: 1218
        • Nelson R.M.
        • Eder W.P.
        • Eddy F.D.
        • Karlson K.E.
        • Dennis C.
        Production of a hemorrhagic state by the infusion of hemolyzed blood.
        in: 6th ed. Proc. Soc. Exper. Biol. & Med.73. 1950: 208-209
        • Ratnoff O.D.
        • Vosburg G.J.
        Observations on the clotting defect in amniotic fluid embolism.
        New England J. Med. 1952; 247: 970-973
        • Ham T.H.
        A Syllabus of Laboratory Examination in Clinical Diagnosis.
        Harvard University Press, Cambridge, Mass1952
        • Seegers W.H.
        Blood Coagulation.
        in: 6th ed. The Enzymes. vol. 1. Academic Press, New York1951
        • Crosby W.H.
        • Stefanini M.
        Pathogenesis of the plasma transfusion reaction with especial reference to the blood coagulation system.
        J. Lab. & Clin. Med. 1952; 40 (and personal communication): 374-386
        • Ratnoff O.D.
        • Conley C.L.
        Studies on afibrinogenemia. II. The defibrinating effect on dog blood of intravenous injection of thromboplastic material.
        Bull. Johns Hopkins Hosp. 1951; 88: 414-424
        • Tagnon H.J.
        • Schulman P.
        • Whitmore W.F.
        • Leone L.A.
        Prostatic fibrinolysin. Study of a case illustrating the role in hemorrhagic diathesis of cancer of the prostate.
        Am. J. Med. 1953; 15: 875-884