Scientific paper| Volume 89, ISSUE 3, P583-592, March 1955

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Alterations in blood coagulation mechanism after incompatible blood transfusion

Clinical and experimental observations
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      • 1.
        1. The hemorrhagic diathasis following an incompatible blood transfusion reaction is associated with thrombocytopenia, prolongation of the coagulation time, prolongation of the prothrombin time, a decrease in the circulating white blood cells, the appearance of fibrinolytic activity and of a “heparinoid” anticoagulant.
      • 2.
        (2) The reaction is somewhat different in dogs inasmuch as the fibrinogen level does not decrease as markedly as in the human case, nor does fibrinolytic activity appear.
      • 3.
        3. It is suggested that the management of these cases be a complete immediate estimate of all the major blood clotting factors with a subsequent replacement of fibrinogen or the use of an antiheparin agent wherever indicated.
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