Scientific paper| Volume 106, ISSUE 1, P64-69, July 1963

Viability, function and myocardial changes of normal and hypertrophied hearts

After insertion of one or more rigid tubes to the full length of the left ventricular myocardium
  • Panagiotis C. Petropoulos
    Athens, Greece

    Stanford University Medical School, Palo Alto, California, USA

    The Institute of Medical Sciences, Presbyterian Medical Center, San Francisco, California, USA
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  • Author Footnotes
    1 From the Department of Surgery, Stanford University Medical School, Palo Alto, California
    2 From the Institute of Medical Sciences, Presbyterian Medical Center, San Francisco, California.
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      Insertion of one or two rigid perforated Tygon or polyethylene tubes throughout the entire length of the left ventricular myocardium was performed in twenty-three dogs. In eight of these, an additional shunt operation was simultaneously or previously performed in order to obtain cardiac hypertrophy. Twenty animals survived, and three died during the second postoperative month. Increase in cardiac output with exercise was well tolerated when one tube was inserted. Blood volumes after insertion of one or two tubes were unchanged. Electrocardiogram changes were similar to those observed in myocardial ischemia. Insertion of the tubes does not produce cardiac hypertrophy nor does it increase cardiac hypertrophy following shunt operations. A connective sheath of 1 to 2 cm. diameter was constantly formed around the tube. This sheath was larger in the areas of perforation and always projected into the lumen of the tube.
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