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Abstract
Fifty-eight cases of cylindroma of the head and neck region, are reviewed. The cylindroma
is a small cell epithelial neoplasm with a cribriform histologic pattern. This neoplasm
infiltrates widely involving almost all types of adjacent tissues, is not limited
by anatomic planes, and shows marked centripetal perineural extension. Although few
patients can be cured, many survive for very long periods with locally recurrent or
metastatic disease. Apparent cure was seen only in six cases in which the initial
excision was shown to be adequate on pathologic examination. Radiotherapy was effective
in temporarily controlling local recurrence and in relieving symptoms of metastases,
but did not result in long term cure in any of these patients. The duration of the
disease is much longer than most other adenocarcinomas. More than half of the patients
who died did so more than five years after initial therapy. Almost all local recurrences
were clinically apparent within eight years, but only half of the patients with local
recurrence were dead within five years of the appearance of recurrent cylindroma.
No case of recurrent cylindroma was cured by either resection or radiotherapy. Distant
metastases did not appear after adequate initial resection. If the primary tumor was
incompletely resected the incidence of distant metastases was twice that of patients
who had received only radiotherapy. Two of twelve patients with submaxillary cylindroma
had associated sialolithiasis.
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© 1965 Published by Elsevier Inc.
