Rapid Communication| Volume 110, ISSUE 4, P519-526, October 1965

Cylindroma (adenoid cystic carcinoma)

A report of fifty-eight cases
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      Fifty-eight cases of cylindroma of the head and neck region, are reviewed. The cylindroma is a small cell epithelial neoplasm with a cribriform histologic pattern. This neoplasm infiltrates widely involving almost all types of adjacent tissues, is not limited by anatomic planes, and shows marked centripetal perineural extension. Although few patients can be cured, many survive for very long periods with locally recurrent or metastatic disease. Apparent cure was seen only in six cases in which the initial excision was shown to be adequate on pathologic examination. Radiotherapy was effective in temporarily controlling local recurrence and in relieving symptoms of metastases, but did not result in long term cure in any of these patients. The duration of the disease is much longer than most other adenocarcinomas. More than half of the patients who died did so more than five years after initial therapy. Almost all local recurrences were clinically apparent within eight years, but only half of the patients with local recurrence were dead within five years of the appearance of recurrent cylindroma. No case of recurrent cylindroma was cured by either resection or radiotherapy. Distant metastases did not appear after adequate initial resection. If the primary tumor was incompletely resected the incidence of distant metastases was twice that of patients who had received only radiotherapy. Two of twelve patients with submaxillary cylindroma had associated sialolithiasis.
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