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Abstract
Studies were carried out on the in vivo staining properties of fifty patients with proved or suspected oral neoplasia. Toluidine
blue, a nuclear stain, was employed, and acetic acid 1 per cent was used for decolorization.
Normal oral mucosa, with certain exceptions, does not stain.
Our studies indicate that in vivo staining with toluidine blue is useful for: (1) the detection of areas of carcinoma
in situ; (2) the recognition of small, early invasive carcinoma; (3) delineation of the margins
of larger epithelial neoplasms; (4) the recognition of postsurgical marginal recurrence;
(5) The recognition of recurrence or new lesions postirradiation; and (6) the delineation
of areas of field cancerization.
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References
- Die Leukoplakie der menschlichen Mundschleimhaut. Mitteilungsdienst der Gesellschaft zur Krebskrankheiten in Nordrhein-Westfalen.December, 1958
- A clinical staining test for the in vivo delineation of dysplasia and carcinoma in situ.Am. J. Obst. & Gynec. 1963; 86: 703
- In vivo staining test for delineation of oral intraepithelial neoplastic change: preliminary report.J. Am. Dent. A. 1964; 68: 801
- A clinicopathologic study of oral carcinoma in situ.Am. J. Surg. 1963; 106: 791
- An analysis of oral cytodiagnosis.Cancer. 1964; 17: 1477
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Footnotes
☆Project supported by a grant from the Connecticut Division, American Cancer Society.
Identification
Copyright
© 1965 Published by Elsevier Inc.
