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Abstract
The preceding discussion serves to re-emphasize that metaplasia to a highly lethal
form of thyroid cancer can occur in the usually indolent papillary thyroid cancer.
When this happens, these patients usually have the ominous signs previously elucidated.
There is recent rapid growth in the thyroid or neck nodes, a large (over 5 cm.) tumor,
and recurrent laryngeal nerve palsy. However, these signs are not always present.
Furthermore, metaplasia may not be manifest in the first material examined histologically.
There may be a long interval from the initial treatment to the appearance of large
areas of metaplasia (twelve and ten years in two of these cases). Metaplasia may be
present in either or both the primary tumor, cervical, or other metastases. Its absence
in the primary lesion does not preclude its appearance in subsequent metastases. This
was demonstrated in two patients in this review. There was metaplasia in a submental
node in one (case IV) and an axillary node in the other (case V) with no evidence
of metaplasia in the primary lesion in either. Once spindle or giant cell metaplasia
is evident in large amounts, the prognosis is grave; the average time until death
is five months.
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References
- Results of treatment of papillary carcinoma of thyroid.Surg. Gynec. & Obst. 1959; 109: 315
- Pathology of thyroid.in: Werner S.C. The Thyroid. 2nd ed. Harper and Row, New York1962: 289
- Papillary cancer of the thyroid: a review of 25 years of experience.Cancer. 1958; 11: 895
- Carcinoma of thyroid gland: statistical study of 390 patients.J. Clin. Endocrinol. 1961; 21: 1596
- Classification and prognosis of thyroid carcinoma, a study of 885 cases observed in 30 yr. period.Am. J. Surg. 1961; 102: 354
- The natural history of thyroid cancer. A review of 301 cases.J. Clin. Endocrinol. 1949; 9: 1023
- Giant cell carcinoma of thyroid.Quart. Bull. Northwestern Univ. M. School. 1962; 36: 375
- Papillary carcinoma of the thyroid. A clinical and pathological study of 70 fatal cases.Cancer. 1964; 17: 1035
- Papillary carcinoma of the thyroid. The case for radical neck dissection.Am. J. Surg. 1964; 108: 547
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© 1965 Published by Elsevier Inc.
