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Research Article| Volume 115, ISSUE 2, P131-139, February 1968

Postoperative changes in the trypsin inhibitor activities of human pancreatic juice and the influence of infusion of trasylol on the inhibitor activity

DOI:https://doi.org/10.1016/0002-9610(68)90020-2
Postoperative changes in the trypsin inhibitor activities of human pancreatic juice and the influence of infusion of trasylol on the inhibitor activity
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      Abstract

      The pancreatic trypsin inhibitor activity in juice obtained from the pancreatic duct by a transduodenal drain after operations on the pancreas and its sphincter mechanisms has been studied in the early postoperative stage.
      Using a pH stat technic with BAEE as the specific enzyme substrate, it was possible to significantly lower the inhibitor activity on the first postoperative day in nine patients who were also able to regain a normal level by the fourth postoperative day.
      It is considered that this finding may be significant in the etiology of postoperative pancreatitis and it is believed that the fall may be explained as a metabolic response to surgical trauma.
      Trasylol, a protease inhibitor, has been infused in the postoperative period with a resulting significant rise in the inhibitory effect of the pancreatic juice. In one patient this rise was accompanied by a marked clinical improvement and clearing of the previously blood-stained pancreatic juice.
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      Article info

      Footnotes

      ☆This work was supported in part by U.S.P.H.S. Grants AM-05277 and AM-11458. A portion of this research was carried out through the Clinical Research Center Facility of the University of Washington, supported by N.I.H. Grant FR-37.

      ☆☆Presented at the Eighth Annual Meeting of the Society for Surgery of the Alimentary Tract, Atlantic City, New Jersey, June 17 and 18, 1967.

      Identification

      DOI: https://doi.org/10.1016/0002-9610(68)90020-2

      Copyright

      © 1968 Published by Elsevier Inc.

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