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Research Article| Volume 115, ISSUE 2, P140-147, February 1968

A five year progress report on the effectiveness of intraluminal chemotherapy (5-fluorouracil) adjuvant to surgery for colorectal cancer

DOI:https://doi.org/10.1016/0002-9610(68)90021-4
A five year progress report on the effectiveness of intraluminal chemotherapy (5-fluorouracil) adjuvant to surgery for colorectal cancer
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      Abstract

      • 1.
        1. Nationwide survival rates after surgery for cancer of the colon and rectum have not improved in the past twenty years.
      • 2.
        2. The modes of spread of cancer of the colorectum are now well known.
      • 3.
        3. A new combined surgical, intraluminal, and systemic chemotherapy regimen has been evolved in our clinic, hopefully to inhibit tumor spread along these pathways and thus enhance survival rates.
      • 4.
        4. A five year clinical experience using 5-FU intraluminally and systemically has been computer-analyzed.
      • 5.
        5. No apparent improvement in survival rates in stage I and II cases (negative nodes) was indicated in the 5-FU treated group versus nationwide averages.
      • 6.
        6. In the positive node group (stage III) the most significant improvement seemingly develops. At five years the cumulative proportion survival rate is 65 per cent for the 5-FU treated group versus 32 per cent in the nationwide (control) series and 26 per cent in the St. Vincent's Hospital (control) series.
      • 7.
        7. This is only a probing study. The authors well recognize the statistical pitfalls of such a small series of cases in a single institution.
      • 8.
        8. Hopefully a multihospital cooperative project with a double blind randomized study design may be achieved, utilizing upwards of 150 cases yearly.
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      Article info

      Footnotes

      ☆Presented at the Eighth Annual Meeting of the Society for Surgery of the Alimentary Tract, Atlantic City, New Jersey, June 17 and 18, 1967.

      Identification

      DOI: https://doi.org/10.1016/0002-9610(68)90021-4

      Copyright

      © 1968 Published by Elsevier Inc.

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