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Abstract
The relationships between gastric secretion, aminopyrine clearance, and A-V difference
were investigated in anesthetized dogs, both with and without vagectomy. From zero
to a constant rate of stimulation, these three parameters in intact dogs changed unidirectionally
and reached similar plateaus. In vagectomized dogs, gastric secretory rate and aminopyrine
clearance did not change, but the A-V difference increased. From these data we have
suggested that mucosal perfusion increases as a consequence of the closure of arteriovenous
shunts, and that this mechanism is in large measure independent of gastric secretory
rate.
Epinephrine administration, isomolar with constant histamine infusion, provoked a
rise in gastric secretion and a fall in A-V difference, suggesting that gastric secretion
has limited dependence on mucosal blood flow.
Finally, we have demonstrated that serotonin is without effect on gastric secretion
or mucosal flow under the conditions of these experiments.
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Article info
Footnotes
☆Presented at the Eighth Annual Meeting of the Society for Surgery of the Alimentary Tract, Atlantic City, New Jersey, June 17 and 18, 1967.
Identification
Copyright
© 1968 Published by Elsevier Inc.
