Research Article| Volume 115, ISSUE 2, P185-190, February 1968

Arteriovenous shunt mechanism in gastric secretion

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      The relationships between gastric secretion, aminopyrine clearance, and A-V difference were investigated in anesthetized dogs, both with and without vagectomy. From zero to a constant rate of stimulation, these three parameters in intact dogs changed unidirectionally and reached similar plateaus. In vagectomized dogs, gastric secretory rate and aminopyrine clearance did not change, but the A-V difference increased. From these data we have suggested that mucosal perfusion increases as a consequence of the closure of arteriovenous shunts, and that this mechanism is in large measure independent of gastric secretory rate.
      Epinephrine administration, isomolar with constant histamine infusion, provoked a rise in gastric secretion and a fall in A-V difference, suggesting that gastric secretion has limited dependence on mucosal blood flow.
      Finally, we have demonstrated that serotonin is without effect on gastric secretion or mucosal flow under the conditions of these experiments.
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        • Thompson J.E.
        • Vane J.R.
        Gastric secretion induced by histamine and its relationship to the rate of blood flow.
        J. Physiol. 1953; 121: 433
        • Jacobson E.D.
        • Scott J.B.
        • Frohlich E.D.
        Hemodynamics of the stomach. II. Relation between gastric secretion and blood flow.
        Am. J. Digest Dis. 1962; 7: 786
        • Peter E.T.
        • Nicoloff D.M.
        • Sosin H.
        • Walder A.I.
        • Wangensteen O.H.
        Relationship between gastric blood flow and secretion.
        in: Fed. Proc.21. 1962: 264
        • Barlow T.E.
        • Bentley F.H.
        • Walder D.N.
        Arteries, veins and arteriovenous anastomoses in the human stomach.
        Surg. Gynec. & Obst. 1951; 93: 657
        • Barclay A.E.
        • Bentley F.H.
        The vascularization of the human stomach.
        Gastroenterology. 1949; 12: 177
        • Walder D.N.
        Arteriovenous anastomoses of the human stomach.
        Clin. Sci. 1952; 11: 59
        • Peters R.M.
        • Womack N.A.
        Hemodynamics of gastric secretion.
        Ann. Surg. 1958; 148: 537
        • Delaney J.P.
        • Grim E.
        Canine gastric blood flow and its distribution.
        Am. J. Physiol. 1964; 207: 1195
        • Hollander F.
        The insulin test for the presence of intact nerve fibers after vagal operations for peptic ulcer.
        Gastroenterology. 1946; 7: 607
        • Shore P.A.
        • Brodie B.B.
        • Hogben C.A.M.
        The gastric secretion of drugs: a pH partition hypothesis.
        J. Pharmacol. & Exper. Therap. 1957; 119: 361
        • Brodie B.B.
        • Axelrod J.
        The fate of aminopyrine (Pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material.
        J. Pharmacol. & Exper. Therap. 1950; 99: 171
        • Jacobson E.D.
        • Linford R.H.
        • Grossman M.I.
        Gastric secretion in relation to mucosal blood flow studied by a clearance technique.
        J. Clin. Invest. 1966; 45: 1
        • Forte J.G.
        • Davies R.E.
        Oxygen consumption and active transport of ions by isolated frog gastric mucosa.
        Am. J. Physiol. 1963; 204: 812
        • Forte J.G.
        • Davies R.E.
        Relation between hydrogen ion secretion and oxygen uptake by gastric mucosa.
        Am. J. Physiol. 1964; 206: 218
        • Planteyat H.T.
        • Willighagen R.C.J.
        Enzyme histochemistry of the human stomach with especial reference to intestinal metaplasia.
        J. Path. & Bact. 1960; 80: 317
        • Menguy R.
        Effects of histamine on gastric blood flow.
        Am. J. Digest. Dis. 1962; 7: 383
        • Nicoloff D.M.
        • Sosin H.
        • Peter E.T.
        • Bernstein E.F.
        • Wangensteen O.H.
        The effect of serotonin on gastric secretion.
        Am. J. Digest. Dis. 1963; 8: 267