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- 1.1. A study was carried out to determine the influence of villous adenoma extracts on in vitro colonic absorption of fluid and electrolytes.
- 2.2. Employing everted gut sacs, it was noted that villous tumor inhibited the net transfer of sodium, potassium, chloride, and fluid across the colon wall of the rat.
- 3.3. Furthermore, by measuring the bidirectional flux of sodium (Na22) across the colonic wall, it was demonstrated that the diminution of net transfer of this ion resulted from an increase in the serosal to mucosal component.
- 4.4. These results are discussed in relation to the hydroelectrolytic depletion syndrome associated with some villous adenomas in man.
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☆This work was supported by U.S.P.H.S. Grant HE-O-2757-11.
☆☆Presented at the Eighth Annual Meeting of the Society for Surgery of the Alimentary Tract, Atlantic City, New Jersey, June 17 and 18, 1967.
© 1968 Published by Elsevier Inc.