Research Article| Volume 115, ISSUE 2, P203-208, February 1968

Maechanism of diarrhea of villous adenomas

      This paper is only available as a PDF. To read, Please Download here.


      • 1.
        1. A study was carried out to determine the influence of villous adenoma extracts on in vitro colonic absorption of fluid and electrolytes.
      • 2.
        2. Employing everted gut sacs, it was noted that villous tumor inhibited the net transfer of sodium, potassium, chloride, and fluid across the colon wall of the rat.
      • 3.
        3. Furthermore, by measuring the bidirectional flux of sodium (Na22) across the colonic wall, it was demonstrated that the diminution of net transfer of this ion resulted from an increase in the serosal to mucosal component.
      • 4.
        4. These results are discussed in relation to the hydroelectrolytic depletion syndrome associated with some villous adenomas in man.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Holmes T.
        Villous tumor of the rectum.
        Tr. Path. Soc. London. 1861; 12: 120
        • McKittrick L.S.
        • Wheelock Jr., F.C.
        Carcinoma of the Colon.
        in: Charles C Thomas, Springfield, Ill1954: 61
      1. DaCruz, G. M. A. and Peskin, G. W. Villous adenoma. To be published.

        • Wilson T.H.
        • Wiseman G.
        Use of sacs of everted small intestine for the study of transference of substances from mucosal to the serosal surface.
        J. Physiol. 1954; 123: 116
        • Harry J.
        The action of drugs on the circular muscle strip from the isolated guinea-pig ileum.
        Brit. J. Pharmacol. 1963; 20: 399
        • Curran P.F.
        Na, Cl and water transport by rat ileum in vitro.
        J. Gen. Physiol. 1960; 43: 1137
        • Gardner J.D.
        • Peskin G.W.
        • Cerda J.J.
        • Brooks F.P.
        Alterations in in vitro fluid and electrolyte absorption by gastrointestinal hormones.
        Am. J. Surg. 1967; 113: 57
        • Curran P.F.
        • Herrera F.C.
        • Flanigan W.J.
        Effect of calcium and antidiuretic hormone on Na transport across frog skin.
        J. Gen. Physiol. 1963; 46: 1011
        • Barry R.J.C.
        • Symth D.H.
        • Wright E.M.
        Short-circuit current and solute transfer by rat jejunum.
        J. Physiol. 1965; 181: 410
        • Duthie H.L.
        • Atwell J.D.
        The absorption of water, sodium, and potassium in the large intestine with particular reference to the effects of villous papillomas.
        GUT. 1963; 4: 373