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A modification of the second look protocol in which 5-fluorouracil was utilized between the time of initial resection and second look is presented. Chemotherapy was employed for the purpose of destroying residual foci of malignancy not recognized at the time of the initial resection. Although the number of cases was small and the duration of follow-up is short, it would appear that this program might be capable of preventing tumor recurrence.
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☆This work was supported by the National Cancer Institute, National Institutes of Health Grant CA-06749.
☆☆Presented at the Eighth Annual Meeting of the Society for Surgery of the Alimentary Tract, Atlantic City, New Jersey, June 17 and 18, 1967.
© 1968 Published by Elsevier Inc.