Scientific paper| Volume 124, ISSUE 3, P325-330, September 1972

Effect of acetic acid on antral phase of gastric secretion after prolonged systemic administration of prednisolone

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      The effect of prolonged intramuscular administration of prednisolone on the antral phase of gastric secretion has been defined in dogs with vagally denervated fundic pouches. In addition, the changes in the secretory response to endogenous gastrin provoked by instillates of acetic acid have been compared before and after prolonged administration of the steroid. After a course of intramuscular prednisolone lasting for approximately six weeks, a standard meat meal evoked higher outputs of H+, but the outputs of Na+ were unchanged. Thus, prednisolone enhanced the antral phase of gastric secretion by a selective effect on parietal secretion. Before prednisolone was given, exposure to acetic acid caused increased exsorption of Na+ without producing hemorrhage from the gastric mucosa. After the systemic administration of the steroid, the organic acid provoked greater exsorption of Na+ and bleeding from the mucosa was constantly observed; nevertheless, the outputs of H+ were still larger than those in the original control tests. These results indicated that acetic acid provoked greater mucosal damage after the administration of prednisolone, but that the damaged mucosa was still able to secrete increased amounts of H+ in response to stimulation by endogenous gastrin augmented by prednisolone.
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        • Flemstrom G
        • Frenning B
        • Obrink KJ
        The disappearance of acetic acid and acetate from the cat's stomach and its influence on the permeability for hydrochloric acid.
        Acta Physiol Scand. 1964; 62: 422
        • Davenport HW
        Gastric mucosal injury by fatty and acetyl salicylic acids.
        Gastroenterology. 1964; 46: 245
        • Davenport HW
        Damage to the gastric mucosa: effects of salicylates and stimulation.
        Gastroenterology. 1965; 49: 189
        • Davenport HW
        Fluid produced by the gastric mucosa during damage by acetic and salicylic acid.
        Gastroenterology. 1966; 50: 487
        • Davenport HW
        • Warner HA
        • Code CF
        Functional significance of gastric mucosal barrier to sodium.
        Gastroenterology. 1964; 47: 142
        • Aubrey DA
        • Burns GP
        Comparison of the effects of acetic acid on the secretory responses of vagally innervated and vagally denervated canine fundic pouches stimulated by endogenous gastrin.
        Arch Surg. 1972; (accepted for publication)
        • Aubrey DA
        • Burns GP
        The effects of topically administered prednisolone and acetic acid on the antral phase of gastric secretion in vagally denervated canine fundic pouches.
        1972 (Submitted for publication)
        • Aubrey DA
        • Burns GP
        The effect of intravenous prednisolone on the secretory response of the vagally denervated gastric mucosa stimulated by endogenous gastrin before and after exposure to acetic acid.
        Arch Surg. 1972; (Accepted for publication)
        • Snedecor GW
        Statistical Methods.
        Iowa State University Press, 1962
        • Aubrey DA
        • Burns GP
        Topically administered prednisolone and the antral phase of gastric secretion.
        Arch Surg. 1972; (accepted for publication)