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Abstract
The effect of prolonged intramuscular administration of prednisolone on the antral
phase of gastric secretion has been defined in dogs with vagally denervated fundic
pouches. In addition, the changes in the secretory response to endogenous gastrin
provoked by instillates of acetic acid have been compared before and after prolonged
administration of the steroid. After a course of intramuscular prednisolone lasting
for approximately six weeks, a standard meat meal evoked higher outputs of H+, but the outputs of Na+ were unchanged. Thus, prednisolone enhanced the antral phase of gastric secretion
by a selective effect on parietal secretion. Before prednisolone was given, exposure
to acetic acid caused increased exsorption of Na+ without producing hemorrhage from the gastric mucosa. After the systemic administration
of the steroid, the organic acid provoked greater exsorption of Na+ and bleeding from the mucosa was constantly observed; nevertheless, the outputs of
H+ were still larger than those in the original control tests. These results indicated
that acetic acid provoked greater mucosal damage after the administration of prednisolone,
but that the damaged mucosa was still able to secrete increased amounts of H+ in response to stimulation by endogenous gastrin augmented by prednisolone.
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References
- The disappearance of acetic acid and acetate from the cat's stomach and its influence on the permeability for hydrochloric acid.Acta Physiol Scand. 1964; 62: 422
- Gastric mucosal injury by fatty and acetyl salicylic acids.Gastroenterology. 1964; 46: 245
- Damage to the gastric mucosa: effects of salicylates and stimulation.Gastroenterology. 1965; 49: 189
- Fluid produced by the gastric mucosa during damage by acetic and salicylic acid.Gastroenterology. 1966; 50: 487
- Functional significance of gastric mucosal barrier to sodium.Gastroenterology. 1964; 47: 142
- Comparison of the effects of acetic acid on the secretory responses of vagally innervated and vagally denervated canine fundic pouches stimulated by endogenous gastrin.Arch Surg. 1972; (accepted for publication)
- The effects of topically administered prednisolone and acetic acid on the antral phase of gastric secretion in vagally denervated canine fundic pouches.1972 (Submitted for publication)
- The effect of intravenous prednisolone on the secretory response of the vagally denervated gastric mucosa stimulated by endogenous gastrin before and after exposure to acetic acid.Arch Surg. 1972; (Accepted for publication)
- Statistical Methods.Iowa State University Press, 1962
- Topically administered prednisolone and the antral phase of gastric secretion.Arch Surg. 1972; (accepted for publication)
Article info
Footnotes
☆This work was supported by grants-in-aid from the National Heart Institute (HE-03181) and the Institute of General Medical Sciences (GM-15768) of the US Public Health Service.
Identification
Copyright
© 1972 Published by Elsevier Inc.
