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The effect of prolonged intramuscular administration of prednisolone on the antral phase of gastric secretion has been defined in dogs with vagally denervated fundic pouches. In addition, the changes in the secretory response to endogenous gastrin provoked by instillates of acetic acid have been compared before and after prolonged administration of the steroid. After a course of intramuscular prednisolone lasting for approximately six weeks, a standard meat meal evoked higher outputs of H+, but the outputs of Na+ were unchanged. Thus, prednisolone enhanced the antral phase of gastric secretion by a selective effect on parietal secretion. Before prednisolone was given, exposure to acetic acid caused increased exsorption of Na+ without producing hemorrhage from the gastric mucosa. After the systemic administration of the steroid, the organic acid provoked greater exsorption of Na+ and bleeding from the mucosa was constantly observed; nevertheless, the outputs of H+ were still larger than those in the original control tests. These results indicated that acetic acid provoked greater mucosal damage after the administration of prednisolone, but that the damaged mucosa was still able to secrete increased amounts of H+ in response to stimulation by endogenous gastrin augmented by prednisolone.
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☆This work was supported by grants-in-aid from the National Heart Institute (HE-03181) and the Institute of General Medical Sciences (GM-15768) of the US Public Health Service.
© 1972 Published by Elsevier Inc.