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Clinical signs and symptoms of perihepatic abscess have become less obvious with the increasing use of antibiotics and corticosteroids. The role of radiologic studies in the diagnosis of suspected perihepatic abscess has increased. Right subphrenic, right subhepatic, intrahepatic, and lesser sac abscesses can present with the same clinical manifestations. The surgical approach is quite different, making accurate anatomic localization necessary. The investigation of a series of cases of perihepatic abscesses from the Johns Hopkins Hospital is reported. The diversity of presentation of such cases is illustrated with examples. The usefulness of abdominal radiographs, liver and lung scans as well as contrast studies is demonstrated. A system for the investigation of suspected abscess in the right upper quadrant is proposed.
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