Advertisement
Scientific paper| Volume 124, ISSUE 3, P363-367, September 1972

Epidemic gram-negative septicemia in surgical patients

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Hospital epidemics of gram-negative infections threaten surgical patients. Septicemia developed in thirteen patients after various surgical procedures in a private urban hospital in September and October 1970, and twelve of these patients yielded gram-negative organisms upon blood culture.
      Clinical signs of thrombophlebitis associated with positive blood cultures in the absence of other reasonable clinical sources of sepsis suggest that intravenous infusion methods were responsible. Patterns of antibiotic resistance and prevalence of usage indicate at least a background of inappropriate antibiotic therapy in the institution as a whole.
      The following recommendations are suggested to obviate future epidemics: (1) laboratory guidance for treatment of hospital infections; (2) careful surveillance of infections in hospitalized patients; (3) meticulous aseptic skin preparation prior to venous cannulations; (4) utilization of stainless steel needles in peripheral veins for short-term needs (that is, forty-eight hours or less) for standard operative procedures; (5) utilization of large caliber upper torso central veins when more durable and reliable long-term venous routes are needed for extensive surgical procedures.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Duma RJ
        • Warner JF
        • Dalton HP
        Septicemia from intravenous infusions.
        New Eng J Med. 1971; 284: 257
        • Glover JL
        • O'Byrne SA
        • Jolly L
        Infusion catheter sepsis: an increasing threat.
        Ann Surg. 1971; 173: 148
        • Mays BB
        • Thomas GD
        • Leonard JS
        • Southern PM
        • Pierce AK
        • Sanford JP
        Gram negative bacillary necrotizing pneumonia. A bacteriologic and histopathologic correlation.
        J Infect Dis. 1969; 120: 687
        • Thoburn R
        • Fekety FR
        • Cluff LC
        • Melvin VB
        Infections acquired by hospitalized patients.
        Arch Intern Med. 1968; 121: 1
        • Weil AJ
        • Ramchand S
        • Arias ME
        Nosocomial infection with Klebsiella type 25.
        New Eng J Med. 1966; 275: 17
        • Pierce AK
        • Sanford JP
        Treatment and prevention of infections associated with inhalation therapy.
        Mod Treatm. 1966; 3: 1171
        • Altemeier WA
        • McDonough JJ
        • Fullen WD
        Third day surgical fever.
        Arch Surg. 1971; 103: 158
        • Banks DC
        • Cawdrey HM
        • Yates DB
        • Harris MG
        Infection from intravenous catheters.
        Lancet. 1970; 1: 443
        • Collins RN
        • Braun PA
        • Zimmer SH
        • Kass EH
        Risk of local and systemic infection with polyethylene intravenous catheters.
        New Eng J Med. 1968; 279: 340
        • Druskin MS
        • Siegel PD
        Bacterial contamination of indwelling intravenous polyethylene catheters.
        JAMA. 1963; 185: 966
        • Smits H
        • Freedman LR
        Prolonged venous catheterization as a cause of sepsis.
        New Eng J Med. 1967; 276: 1229
        • Moran JM
        • Atwood RP
        • Rowe MI
        A clinical and bacteriologic study of infections associated with venous cut downs.
        New Eng J Med. 1965; 272: 554
        • Zimmer SH
        • Denny-Brown BC
        • Braun P
        • Burke JP
        • Toala P
        • Kass EH
        Risk of infection with intravenous indwelling catheters: effect of application of antibiotic ointment.
        J Infect Dis. 1969; 120: 616
        • Norden CW
        Application of antibiotic ointment to the site of venous catheterization: a controlled trial.
        J Infect Dis. 1969; 120: 611
        • Weakley SD
        • Mays ET
        Percutaneous catheterization of the subclavian vein in various clinical situations.
        JAMA. 1969; 67: 902
        • Mays ET
        A microbiologic investigation of central venous catheters: a personal prospective study.
        Southern Med J. 1972; 65: 830
        • Finland M
        Changes in susceptibility of selected pathogenic bacteria to widely used antibiotics.
        Ann NY Acad Sci. 1971; 182: 5
        • Rose HD
        • Schreier J
        The effect of hospitalization and antibiotic therapy on the gram-negative fecal flora.
        Amer J Med Sci. 1969; 255: 228
        • Mummery RV
        • Bradley JM
        • Jefferies DJ
        Microbiological monitoring of patients in hepatic failure with particular reference to extracorporeal porcine liver perfusion.
        Lancet. 1971; 2: 60
        • Eickhoff TC
        • Steinhauer BW
        • Finland M
        The Klebsiella-Enterobacter-Serratia division.
        Ann Intern Med. 1966; 65: 1163
        • Marples RR
        • Fulton JE
        • Leyden J
        • McGinley KJ
        Effect of antibiotics on the nasal flora in acne patients.
        Arch Derm. 1969; 99: 647
        • Cooke EM
        • Breaden AL
        • Shooter RA
        • O'Farrell SM
        Antibiotic sensitivity of Escherichia coli isolated from animals, food, hospital patients and normal people.
        Lancet. 1971; 2: 8
        • Smith HW
        Observations on the in vivo transfer of R factors.
        Ann NY Acad Sci. 1971; 182: 80
        • Isenberg HD
        • Berkman JI
        The role of drug-resistant and drug selected bacteria in nosocomial disease.
        Ann NY Acad Sci. 1971; 182: 52
      1. Altemeier WA: Personal communication.