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Treatment of locally advanced breast carcinoma by the accepted modalities is frequently followed by local failure, acceleration of metastases, or crippling complications of the therapy itself.
A preliminary case report is therefore made of successful local treatment utilizing a zinc chloride paste fixative. The surface of the carcinoma was thereby destroyed to a depth of about 5 mm, this dead peel being excised virtually without pain at the patient's bedside. A successive coating of fixative was then applied, and subsequently destroyed cancer excised until histologically normal tissue was reached. A skin graft to the granulating base completed the local care of the wound.
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