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Abstract
The changes in the secretory response to a meat meal, after preliminary exposure of
vagally innervated and vagally denervated fundic pouches to ox bile at pH 7 and pH
2, have been defined. In the innervated pouches, exposure to bile at both pH levels
caused transient inhibition of gastric acid secretion. In both types of pouch, the
output of Na+ in the gastric juice was persistently increased due to enhanced exchange diffusion.
The changes were more pronounced after exposure to bile at pH 2 than after exposure
to bile at pH 7. After exposure to bile, exchange diffusion was more increased in
the innervated pouches than in the denervated. The results suggested that the innervated
mucosa was more susceptible than was the denervated mucosa to the injurious effects
of bile.
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References
- Destruction of the gastric mucosal barrier by detergents and urea.Gastroenterology. 1968; 54: 175
- Bile damage to the gastric mucosal barrier: the influence of pH and bile acid concentration.Gastroenterology. 1971; 61: 178
- The effect of acetic acid on gastric secretion stimulated by endogenous gastrin in vagally denervated canine fundic pouches.Am J Dig Dis. 1973; 18: 99
- Secretory responses of canine fundic pouches: effects of acetic acid on antral phase.Arch Surg. 1972; 104: 672
- Gastric acid rebound: a review.Gastroenterology. 1959; 37: 145
Article info
Footnotes
☆This work was supported by grants from the National Heart Institute (HE-03181) and the Institute of General Medical Sciences (GM-15768) of the US Public Health Service.
Identification
Copyright
© 1975 Published by Elsevier Inc.
