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Abstract
The relationship between changes in glucose tolerance and in mitochondrial phosphorylative
activity was studied after massive liver resection. In rabbits twenty-four hours after
hepatectomy, when the phosphorylative activity in the mitochondria of the remnant
liver was enhanced maximally, the blood glucose level did not increase significantly
after glucose administration. Fortyeight hours after hepatectomy, when the phosphorylative
activity decreased to a submaximal level, the blood glucose level increased gradually
but without a return toward normal. About six weeks after partial hepatectomy, mitochondrial
function returned gradually to normal levels and the glucose tolerance test results
returned to within normal limits. Considering the previous report that an enhancement
of mitochondrial phosphorylative activity is required for a later increase in nuclear
DNA synthesis, it was suggested that the plateau pattern, with hypoglycemia, and the
gradual increase, with a prolonged return toward normal, in the glucose tolerance
test are indicative of marked enhancement of mitochondrial phosphorylative activity
preceding an increase in nuclear DNA synthesis. The changes in the glucose tolerance
test results in hepatectomized rabbits also were observed in rats and in man; however,
they were more rapid in rats and slower in man. From these results it was suggested
that the glucose tolerance test is very useful in the evaluation of the stage of regeneration
in the liver remnant after massive liver resection.
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Article info
Footnotes
☆This work was supported by grants from the Scientific Research Fund of the Ministry of Education, the Japanese Association for Study of Metabolism and Disease, and Miura Scientific Research Fund.
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Copyright
© 1975 Published by Elsevier Inc.
