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Abstract
The histopathologic features of 34 resected carcinomas of the upper bile duct were
reviewed. Patients with papillary adenocarcinoma showed a 3-year survival rate of
75 percent, which was better than those with poorly differentiated adenocarcinoma
with no 2-year survivors. Infiltration to the serosa of the bile duct, lymph node
metastasis, and vascular invasion were important prognostic factors, since the survival
was better for the patients without than those with these factors. Among patients
with papillary adenocarcinoma, none had hepatic infiltration and lymph node metastasis
and most had no infiltration to the serosa. Patients with poorly differentiated adenocarcinoma,
in contrast, had extensive association of those prognostic factors. Seventy-five percent
of the patients with papillary adenocarcinoma and only 22 percent of patients with
poorly differentiated adenocarcinoma were considered to have curative resection. These
findings suggest that the histologic type strongly influenced the prognosis of the
patients with carcinoma of the upper bile duct and can be used for the determination
of the extent of this tumor.
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© 1989 Published by Elsevier Inc.
