Scientific paper| Volume 157, ISSUE 6, P557-561, June 1989

Download started.


Operative therapy of gallbladder disease in patients with cystic fibrosis

      This paper is only available as a PDF. To read, Please Download here.


      We retrospectively studied 20 patients with cystic fibrosis who underwent surgery for gallbladder disease from 1973 to 1986. A long delay between the onset of symptoms and the diagnosis was noted (mean 7.4 months). This delay was attributed to masking of the symptoms of biliary disease by the malabsorption and pulmonary symptoms seen in this patient population. There was a notable lack of common bile duct disease in our patients as well as in those reported in the literature. This may have been due to a combination of factors: the increased viscosity of the mucus, the small caliber of the gallbladder and ductal system, and the hypotonicity of the gallbladder. We do not recommend routine intraoperative cholangiography in patients with cystic fibrosis and gallbladder disease.
      Cystic fibrosis is a disease with progressive pulmonary deterioration. Cholecystectomy can be performed in these patients with relative safety if careful preoperative and postoperative care is provided. We recommend early operative intervention in the patient with gallbladder disease and cystic fibrosis.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Bodian M
        Fibrocystic disease of the pancreas.
        Heinemann, London1952
        • Wilson-Sharp RC
        • Irving HC
        • Brown RC
        • et al.
        Ultrasonography of the pancreas, liver, and biliary system in cystic fibrosis.
        Arch Dis Child. 1984; 59: 923-926
        • Stern RC
        • Rothstein FC
        • Doershuk CF
        Treatment and prognosis of symptomatic gallbladder disease in patients with cystic fibrosis.
        J Pediatr Gastroenterol Nutr. 1986; 5: 35-40
        • Rovsing H
        • Sloth K
        Micro-gallbladder and biliary calculi in mucoviscidosis.
        Acta Radiol. 1973; 14: 588-592
        • Roy CC
        • Weber AM
        • Morin CL
        Abnormal biliary lipid composition in cystic fibrosis: effect of pancreatic enzymes.
        N Engl J Med. 1977; 297: 1301-1305
        • L'Heureux PR
        • Isenberg NJ
        • Sharp HL
        • et al.
        Gallbladder disease in cystic fibrosis.
        AJR. 1977; 128: 953-956
        • Forstner G
        • Wesley A
        • Forstner J
        Clinical aspects of gastrointestinal mucus.
        Adv Exp Med Biol. 1982; 144: 199-224
        • Roy CC
        • Weber AM
        • Morin CL
        • et al.
        Hepatobiliary disease in cystic fibrosis: a survey of current issues and concepts.
        J Pediatr Gastroenterol Nutr. 1982; 1: 469-478